Segregational drift and the interplay between plasmid copy number and evolvability

J Ilhan, A Kupczok, C Woehle, T Wein… - Molecular biology …, 2019 - academic.oup.com
The ubiquity of plasmids in all prokaryotic phyla and habitats and their ability to transfer
between cells marks them as prominent constituents of prokaryotic genomes. Many …

Segregational drift constrains the evolutionary rate of prokaryotic plasmids

A Garoña, NF Hülter, D Romero Picazo… - Molecular Biology and …, 2021 - academic.oup.com
Plasmids are extrachromosomal genetic elements in prokaryotes that have been recognized
as important drivers of microbial ecology and evolution. Plasmids are found in multiple …

Intracellular competitions reveal determinants of plasmid evolutionary success

NF Hülter, T Wein, J Effe, A Garoña… - Frontiers in Microbiology, 2020 - frontiersin.org
Plasmids are autonomously replicating genetic elements that are ubiquitous in all taxa and
habitats where they constitute an integral part of microbial genomes. The stable inheritance …

Progress towards understanding the fate of plasmids in bacterial communities

FR Slater, MJ Bailey, AJ Tett… - FEMS microbiology …, 2008 - academic.oup.com
Plasmid-mediated horizontal gene transfer influences bacterial community structure and
evolution. However, an understanding of the forces which dictate the fate of plasmids in …

Evolution and population genetics of bacterial plasmids

CM Thomas - Plasmid biology, 2004 - Wiley Online Library
The distinction between plasmids and chromosomes has been blurred by the discovery of
megaplasmids and small chromosomes through the use of pulsed‐field gel electrophoresis …

Fitness costs of plasmids: a limit to plasmid transmission

A San Millan, RC MacLean - Microbiology spectrum, 2017 - Am Soc Microbiol
Plasmids mediate the horizontal transmission of genetic information between bacteria,
facilitating their adaptation to multiple environmental conditions. An especially important …

Mobile compensatory mutations promote plasmid survival

M Zwanzig, E Harrison, MA Brockhurst, JPJ Hall… - Msystems, 2019 - Am Soc Microbiol
The global dissemination of plasmids encoding antibiotic resistance represents an urgent
issue for human health and society. While the fitness costs for host cells associated with …

Mosaic plasmids are abundant and unevenly distributed across prokaryotic taxa

MW Pesesky, R Tilley, DAC Beck - Plasmid, 2019 - Elsevier
Mosaic plasmids, plasmids composed of genetic elements from distinct sources, are
associated with the spread of antibiotic resistance genes. Transposons are considered the …

Beyond horizontal gene transfer: the role of plasmids in bacterial evolution

J Rodríguez-Beltrán, J DelaFuente… - Nature Reviews …, 2021 - nature.com
Plasmids have a key role in bacterial ecology and evolution because they mobilize
accessory genes by horizontal gene transfer. However, recent studies have revealed that …

Plasmid interactions can improve plasmid persistence in bacterial populations

JA Gama, R Zilhão, F Dionisio - Frontiers in Microbiology, 2020 - frontiersin.org
It is difficult to understand plasmid maintenance in the absence of selection and theoretical
models predict the conditions for plasmid persistence to be limited. Plasmid-associated …