Listeria monocytogenes is an intracellular organism that has the unusual ability to live in the
cytoplasm of the cell. It is thus a good vector for targeting protein antigens to the cellular arm …

The facultative intracellular bacterium Listeria monocytogenes (Lmo) has great potential for
development as a cancer vaccine platform given its properties. However, the clinical …

Pancreatic ductal adenocarcinoma (PDA) is accompanied by reprogramming of the local
microenvironment, but changes at distal sites are poorly understood. We implanted …

Pancreatic ductal adenocarcinoma carries a dismal prognosis, and outcomes have
improved little with modern therapeutics. Checkpoint-based immunotherapy has failed to …

The microbiota plays a key role in regulating the innate and adaptive immune system.
Herein, we review the immunological aspects of the microbiota in tumor immunity in mice …

We report a method of cancer immunotherapy using an attenuated Salmonella typhimurium
strain engineered to secrete Vibrio vulnificus flagellin B (FlaB) in tumor tissues. Engineered …

The ability of some tumors to exclude effector T cells represents a major challenge to
immunotherapy. T cell exclusion is particularly evident in pancreatic ductal adenocarcinoma …

Active immunotherapy targeting dendritic cells (DCs) has shown great promise in preclinical
models and in human clinical trials for the treatment of malignant disease. Sipuleucel-T …

T-cell exhaustion is a phenomenon that represents the dysfunctional state of T cells in
chronic infections and cancer and is closely associated with poor prognosis in many …

ABSTRACT Pancreatic Ductal Adenocarcinoma (PDA) is characterized by a complex tumor
microenvironment that supports its progression, aggressiveness and resistance to therapies …