P Pymm, A Adair, LJ Chan… - Proceedings of the …, 2021 - National Acad Sciences
Neutralizing antibodies are important for immunity against SARS-CoV-2 and as therapeutics for the prevention and treatment of COVID-19. Here, we identified high-affinity nanobodies …
Antibodies binding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike have therapeutic promise, but emerging variants show the potential for virus escape …
Y Lu, Q Li, H Fan, C Liao, J Zhang, H Hu… - International journal …, 2023 - Taylor & Francis
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants have risen to dominance, which contains far more mutations in the spike protein in …
MA Rossotti, H van Faassen, AT Tran, J Sheff… - Communications …, 2022 - nature.com
Nanobodies offer several potential advantages over mAbs for the control of SARS-CoV-2. Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern …
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) Omicron variant sub- lineages spread rapidly worldwide, mostly due to their immune-evasive properties. This has …
The spike glycoprotein of SARS-CoV-2 engages with human ACE 2 to facilitate infection. Here, we describe an alpaca-derived heavy chain antibody fragment (VHH), saRBD-1, that …
The severe acute respiratory syndrome (SARS-CoV-2), a newly emerging of coronavirus, continues to infect humans in the absence of a viable treatment. Neutralizing antibodies that …
JM Zupancic, JS Schardt, AA Desai… - Advanced …, 2021 - Wiley Online Library
The COVID‐19 pandemic continues to be a severe threat to human health, especially due to current and emerging SARS‐CoV‐2 variants with potential to escape humoral immunity …
AP Chapman, X Tang, JR Lee, A Chida, K Mercer… - Scientific Reports, 2021 - nature.com
The need for high-affinity, SARS-CoV-2-specific monoclonal antibodies (mAbs) is critical in the face of the global COVID-19 pandemic, as such reagents can have important diagnostic …