[HTML][HTML] Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

X Chi, X Liu, C Wang, X Zhang, X Li, J Hou… - Nature …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads worldwide and
leads to an unprecedented medical burden and lives lost. Neutralizing antibodies provide …

Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants

J Hong, HJ Kwon, R Cachau… - Proceedings of the …, 2022 - National Acad Sciences
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is a trimer of
S1/S2 heterodimers with three receptor-binding domains (RBDs) at the S1 subunit for …

Applications of nanobodies in the prevention, detection, and treatment of the evolving SARS-CoV-2

W Wang, Y Hu, B Li, H Wang, J Shen - Biochemical Pharmacology, 2023 - Elsevier
Global health and economy are deeply influenced by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and its newly emerging variants. Nanobodies with nanometer …

[HTML][HTML] A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

J Huo, H Mikolajek, A Le Bas, JJ Clark… - Nature …, 2021 - nature.com
SARS-CoV-2 remains a global threat to human health particularly as escape mutants
emerge. There is an unmet need for effective treatments against COVID-19 for which …

[HTML][HTML] Nanobodies: prospects of expanding the gamut of neutralizing antibodies against the novel coronavirus, SARS-CoV-2

R Konwarh - Frontiers in immunology, 2020 - frontiersin.org
With more than 6.9 M confirmed cases and~ 400 K deaths as on June 8, 2020 (1), COVID-
19, ushered in by the SARS-CoV-2 has projected itself as a microscopic-holocaust, much …

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

PJM Brouwer, TG Caniels, K van der Straten… - Science, 2020 - science.org
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
had a large impact on global health, travel, and economy. Therefore, preventative and …

Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2

Y Xiang, S Nambulli, Z Xiao, H Liu, Z Sang, WP Duprex… - Science, 2020 - science.org
Cost-effective, efficacious therapeutics are urgently needed to combat the COVID-19
pandemic. In this study, we used camelid immunization and proteomics to identify a large …

[PDF][PDF] Potent neutralization of SARS-CoV-2 in vitro and in an animal model by a human monoclonal antibody

W Li, A Drelich, DR Martinez, L Gralinski, C Chen… - BioRxiv, 2020 - researchgate.net
Effective therapies are urgently needed for the SARS-CoV-2/COVID19 pandemic. We
identified panels of fully human monoclonal antibodies (mAbs) from eight large …

[HTML][HTML] Omicron: a heavily mutated SARS-CoV-2 variant exhibits stronger binding to ACE2 and potently escapes approved COVID-19 therapeutic antibodies

M Shah, HG Woo - Frontiers in immunology, 2022 - frontiersin.org
The new SARS-CoV-2 variant of concern “Omicron” was recently spotted in South Africa and
spread quickly around the world due to its enhanced transmissibility. The variant became …

[HTML][HTML] Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

H Ma, Y Guo, H Tang, CTK Tseng, L Wang, H Zong… - Cell discovery, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs)
continue to wreak havoc across the globe. Higher transmissibility and immunologic …