Characterization of genomic regulation profiles in human mitral valve whole tissue to annotate genetic risk loci for mitral valve prolapse

S Kyryachenko, A Georges, M Yu, T Barrandou… - medRxiv, 2020 - medrxiv.org
Rationale Mitral valve prolapse (MVP) is a common valve disease that leads to mitral
insufficiency, heart failure and sudden death. The identification of risk loci provided insight …

Chromatin accessibility of human mitral valves and functional assessment of MVP risk loci

S Kyryachenko, A Georges, M Yu, T Barrandou… - Circulation …, 2021 - Am Heart Assoc
Rationale: Mitral valve prolapse (MVP) is a common valvopathy that leads to mitral
insufficiency, heart failure, and sudden death. Functional genomic studies in mitral valves …

Genome-wide association meta-analysis supports genes involved in valve and cardiac development to associate with mitral valve prolapse

M Yu, S Kyryachenko, S Debette… - Circulation: Genomic …, 2021 - Am Heart Assoc
Background: Mitral valve prolapse (MVP) is a common cardiac valve disease, which affects
1 in 40 in the general population. Previous genome-wide association study has identified 6 …

0207: Functional explorations of genes near genetic risk loci for mitral valve prolapse involve TNS1 and LMCD1 in valve development and integrity

N Bouatia-Naji, C Dina, N Tucker, K Toomer… - Archives of …, 2015 - Elsevier
Nonsyndromic mitral valve prolapse (MVP) is a common degenerative valvulopathy of
unknown aetiology that predisposes to heart failure and sudden death. Here we investigate …

Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse

C Roselli, M Yu, V Nauffal, A Georges… - European heart …, 2022 - academic.oup.com
Aims Mitral valve prolapse (MVP) is a common valvular heart disease with a prevalence of>
2% in the general adult population. Despite this high incidence, there is a limited …

Genome-Wide Association Study–Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse

M Yu, A Georges, NR Tucker… - Circulation: Genomic …, 2019 - Am Heart Assoc
Background Mitral valve prolapse (MVP) is a common heart valve disease, the most frequent
indication for valve repair or replacement. MVP is characterized by excess extracellular …

Genome wide association study meta-analysis of 19,487 individuals with mitral valve prolapse identifies 52 novel genomic regions and highlights pro-fibrosis genes

A Small, TE Berrandou, A Georges, J Morningstar… - Circulation, 2024 - ahajournals.org
Introduction: Mitral valve prolapse (MVP) is the most common cause of primary mitral
regurgitation and is estimated to affect between 1-3% of the general population. A subset of …

[HTML][HTML] Genetics of mitral valve prolapse and its clinical impact

AA Chahal, N Bouatia-Naji - J Cardiol Pract, 2019 - escardio.org
Mitral valve prolapse (MVP) is the most frequent valvular abnormality, associated with
various degrees of incompetence and sequelae including heart failure and sudden death …

Primary cilia defects causing mitral valve prolapse

KA Toomer, M Yu, D Fulmer, L Guo, KS Moore… - Science translational …, 2019 - science.org
Mitral valve prolapse (MVP) affects 1 in 40 people and is the most common indication for
mitral valve surgery. MVP can cause arrhythmias, heart failure, and sudden cardiac death …

GWAS-driven Pathway Analyses and Functional Validation Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse

M Yu, A Georges, NR Tucker, S Kyryachenko… - bioRxiv, 2018 - biorxiv.org
Nonsyndromic Mitral valve prolapse (MVP) is a common degenerative valvular heart
disease with severe health consequences, including arrhythmia, heart failure and sudden …