Hepsin, a type II transmembrane serine protease, is upregulated in prostate cancer and
known to be involved in the progression of metastasis. Here we report a structure-guided …

BACKGROUND Hepsin is a cell surface protease that is over‐expressed in more than 90%
of human prostate cancer cases. The previously developed Probasin‐hepsin/Large …

Hepcidin is a liver-derived hormone with a key role in iron homeostasis. In addition to iron, it
is regulated by inflammation and hypoxia, although mechanisms of hypoxic regulation …

Cell surface proteolysis is important for the generation of bioactive proteins mediating tumor
progression. Recent studies suggest that the membrane‐anchored cell surface proteinases …

Hepsin is a type II transmembrane serine protease that is expressed in several human
tissues. Overexpression of hepsin has been found to correlate with tumour progression and …

Hepsin is an integral membrane protein that may participate in cell growth and in
maintaining proper cell morphology and is overexpressed in a number of primary tumors …

Introduction 3. Hepsin cDNA and gene structures 3.1. Cloning of hepsin cDNA 3.2. Hepsin
gene structure 3.3. The promoter sequence of the mouse hepsin gene. 4. Hepsin protein 4.1 …

Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic
iron homeostasis through its interaction with ferroportin, the major cellular iron export …

Purpose: Other cDNA microarray studies have shown that hepsin is one of the highly over
expressed genes in prostate cancer tissue compared with nonmalignant and benign …

Hepcidin is the key regulator of systemic iron availability that acts by controlling the
degradation of the iron exporter ferroportin. It is expressed mainly in the liver and regulated …