Microtubules are found in almost all eukaryotic cells and serve a number of important
functions in cell motility. They are the principal structural comн ponents of the mitotic spindle …

It has been thought that motile structures within the cell are driven toward the plus and minus
ends of microtubules by the ATPases, kinesin and dynein, respectively. Recently obtained …

Many of the motions by and within cells are dependent on mechanochemical enzymes that
interact with cytoplasmic filaments to generate force. For example, myosin interacts with …

Cellular polarization dependsuponthe asymmetrictransport of componentswithin the cell,
often along microtubule paths. Kinesin and cytoplasmic dynein are the most abundant …

Microtubules (MTs) play a fundamental role in a number of processes necessary for cell
growth, proliferation, and survival. Originally recognized as one of the major players in …

Microtubule-based motility is precisely regulated, and the targets of regulation may be the
motor proteins, the microtubules, or both components of this intricately controlled system …

Among the most interesting proteins associated with microtubules are the energy-
transducing ATPases, known as microtubule motors. These motor proteins, which. are able …

Microtubules participate in a wide variety of cellular functions such as the maintenance of
cell shape, particle and organelle movements, the separation of chromosomes on the mitotic …

Three classes of cytoskeletal motor protein have been identified—myosins, kinesins and
dyneins. Together, these proteins are now thought to be responsible for the remarkable …

Organelle transport along microtubules can be reconstituted using isolated components,
allowing this complex motility process to be dissected biochemically. This approach has led …