Silymarin is a complex of five major compounds, and silibinin is the most biologically active
component of the complex. The aim of this study was to investigate, evaluate and confirm the …

Purpose Although doxorubicin chemotherapy is commonly applied for treating different
malignant tumors, cardiotoxicity induced by this chemotherapeutic agent restricts its clinical …

Cardiac disorders remain one of the most important causes of death in the world. Oxidative
stress has been suggested as one of the molecular mechanisms involved in drug-induced …

Adriamycin is a potent anticancer agent, its clinical use is limited for its marked cardiotoxicity
and nephrotoxicity. The present study aimed to investigate the possible protective role of the …

One of the biggest factors that negatively affect the cancer treatment plan is the toxic effects
of chemotherapeutics on non-target cells and tissues. This information prompted us to …

Objectives The aim of the present study was to investigate the effect of silymarin on
doxorubicin-induced toxicity to the rat kidney, heart, and liver. Materials and methods A …

The benefit of silymarin, a plant extract with strong antioxidant activity against hepatotoxicity
induced by cisplatin in rats was investigated in this study. Cisplatin is one of the most …

Objectives: The aim of this study was to investigate mechanisms involved in the growth
inhibitory effect of silymarin, in humanhepatocellular carcinoma. Materials and Methods: The …

Widespread use of herbal drugs because of their protective effects on different organs
toxicity has been shown in many studies. These protective effects have been illustrated in …

Silymarin, an extract of flavonolignans from the dried fruits of milk thistle (Silybum marianum
L. Gaertneri) and its constituents silibinin, dehydrosilibinin, silychristin and silydianin were …