To determine whether initial nociceptive inputs caused by subcutaneous injection of formalin
into the hindpaw are necessary and/or sufficient for allodynic behavior and microglial …

Subcutaneous (sc) injection of formalin induces a rapid and prolonged hyperalgesia across
widespread areas of the body. This hyperalgesic state involves a brain-to-spinal cord …

The formalin test produces 2 well-known acute phases of nociceptive behavior. Recently, we
have shown that this same formalin test produces a third phase of nociceptive behavior …

Injection of formalin into a hind paw of rats produces localized inflammation and pain. The
nociceptive effect of formalin, recorded as flinching/shaking of the injected paw, is biphasic …

Subcutaneous formalin injection has been used extensively to evaluate acute effects (over
several hours) of chemical nociceptive stimulation on nociceptive reflexes. Also, a persistent …

Microglia in primary afferent projection territories are activated and proliferate after
peripheral nerve injury. However, it is not known whether stimulation of peripheral nerves by …

Previous work has demonstrated that pain facilitation can occur following injection of
subcutaneous irritants, such as formalin. Such studies have focused on apparent pain …

The purpose of this study was to investigate whether 1%, 2% or 5% formalin injection
produce hypersensitivity with characteristics of the neuropathic pain induced by spinal nerve …

Subcutaneous formalin injection is widely used as a nociceptive stimulus in the rat. This
procedure evokes overt behaviors that last about 90 minutes. However, little is known about …

Neural plasticity of afferent pain pathways that is induced by prolonged or repeated noxious
stimuli may contribute to activate intrinsic inhibitory mechanisms in CNS. In order to clarify …