Plasmid persistence in bacterial populations is strongly influenced by the fitness effects
associated with plasmid carriage. However, plasmid fitness effects in wild-type bacterial …

The current epidemic of antibiotic resistance has been facilitated by the wide and rapid
horizontal dissemination of antibiotic resistance genes (ARGs) in microbial communities …

It is difficult to understand plasmid maintenance in the absence of selection and theoretical
models predict the conditions for plasmid persistence to be limited. Plasmid-associated …

Plasmids are genetic elements that play a role in bacterial evolution by providing new genes
that promote adaptation to diverse conditions. Plasmids are also known to reduce bacterial …

Abstract The World Health Organization has declared the emergence of antibiotic resistance
to be a global threat to human health. Broad-host-range plasmids have a key role in causing …

Plasmids are extrachromosomal DNA elements that can be found throughout bacteria, as
well as in other domains of life. Nonetheless, the evolutionary processes underlying the …

Plasmids mediate the horizontal transmission of genetic information between bacteria,
facilitating their adaptation to multiple environmental conditions. An especially important …

Multidrug resistant bacterial pathogens have become a serious global human health threat,
and conjugative plasmids are important drivers of the rapid spread of resistance to last …

Plasmid acquisition is an important mechanism of rapid adaptation and niche expansion in
prokaryotes. Positive selection for plasmid-coded functions is a major driver of plasmid …

Conjugative plasmids play a key role in the dissemination of antimicrobial resistance (AMR)
genes across bacterial pathogens. AMR plasmids are widespread in clinical settings, but …