The spread of LAGLIDADG homing endonuclease genes in rDNA

P Haugen, D Bhattacharya - Nucleic acids research, 2004 - academic.oup.com
Group I introns that encode homing endonuclease genes (HEGs) are highly invasive genetic
elements. Their movement into a homologous position in an intron‐less allele is termed …

The evolution of homing endonuclease genes and group I introns in nuclear rDNA

P Haugen, V Reeb, F Lutzoni… - Molecular Biology and …, 2004 - academic.oup.com
Group I introns are autonomous genetic elements that can catalyze their own excision from
pre-RNA. Understanding how group I introns move in nuclear ribosomal (r) DNA remains an …

Homing endonuclease structure and function

BL Stoddard - Quarterly reviews of biophysics, 2005 - cambridge.org
Homing endonucleases are encoded by open reading frames that are embedded within
group I, group II and archael introns, as well as inteins (intervening sequences that are …

The LAGLIDADG homing endonuclease family

B Chevalier, RJ Monnat, BL Stoddard - Homing endonucleases and …, 2005 - Springer
The LAGLIDADG protein family includes the first identified and biochemical# ly
characterized intron# encoded proteins (Dujon 19801 Lazowska et al. 19801 Jacquier and …

Expression of protein-coding genes embedded in ribosomal DNA

SD Johansen, P Haugen, H Nielsen - 2007 - degruyter.com
Ribosomal DNA (rDNA) is a specialised chromosomal location that is dedicated to high-
level transcription of ribosomal RNA genes. Interestingly, rDNAs are frequently interrupted …

Adaptation of intronic homing endonuclease for successful horizontal transmission

S Kurokawa, Y Bessho, K Higashijima… - The FEBS …, 2005 - Wiley Online Library
Group I introns are thought to be self‐propagating mobile elements, and are distributed over
a wide range of organisms through horizontal transmission. Intron invasion is initiated …

LAHEDES: the LAGLIDADG homing endonuclease database and engineering server

GK Taylor, LH Petrucci, AR Lambert… - Nucleic acids …, 2012 - academic.oup.com
LAGLIDADG homing endonucleases (LHEs) are DNA cleaving enzymes, also termed
'meganucleases' that are employed as gene-targeting reagents. This use of LHEs requires …

DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoI

KE Flick, MS Jurica, RJ Monnat Jr, BL Stoddard - Nature, 1998 - nature.com
Homing endonucleases are a diverse collection of proteins that are encoded by genes with
mobile, self-splicing introns,,. They have also been identified in self-splicing inteins (protein …

The recent transfer of a homing endonuclease gene

P Haugen, OG Wikmark, A Vader… - Nucleic acids …, 2005 - academic.oup.com
The myxomycete Didymium iridis (isolate Panama 2) contains a mobile group I intron named
Dir. S956-1 after position 956 in the nuclear small subunit (SSU) rRNA gene. The intron is …

Rapid evolution of the DNA-binding site in LAGLIDADG homing endonucleases

P Lucas, C Otis, JP Mercier, M Turmel… - Nucleic acids …, 2001 - academic.oup.com
Sequence analysis of chloroplast and mitochondrial large subunit rRNA genes from over 75
green algae disclosed 28 new group I intron-encoded proteins carrying a single …