[HTML][HTML] Molnupiravir: A versatile prodrug against SARS-CoV-2 variants

D Teli, P Balar, K Patel, A Sharma, V Chavda, L Vora - Metabolites, 2023 - mdpi.com
The nucleoside analog β-DN 4-hydroxycytidine is the active metabolite of the prodrug
molnupiravir and is accepted as an efficient drug against COVID-19. Molnupiravir targets the …

Human safety, tolerability, and pharmacokinetics of molnupiravir, a novel broad-spectrum oral antiviral agent with activity against SARS-CoV-2

WP Painter, W Holman, JA Bush… - Antimicrobial agents …, 2021 - Am Soc Microbiol
ABSTRACT Molnupiravir (EIDD-2801/MK-4482), the prodrug of the active antiviral
ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931), has activity against a …

[引用][C] COVID antiviral pills: what scientists still want to know

H Ledford - Nature, 2021 - ideas.repec.org
COVID antiviral pills: what scientists still want to know IDEAS home Advanced search
Economic literature: papers, articles, software, chapters, books. Authors Institutions …

Quinoline and quinazoline derivatives inhibit viral RNA synthesis by SARS-CoV-2 RdRp

J Zhao, Y Zhang, M Wang, Q Liu, X Lei… - ACS infectious …, 2021 - ACS Publications
Coronavirus disease 2019 (COVID-19) is a fatal respiratory illness caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The identification of potential drugs is …

[HTML][HTML] Oral GS-441524 derivatives: Next-generation inhibitors of SARS‐CoV‐2 RNA‐dependent RNA polymerase

Z Wang, L Yang, X Song - Frontiers in Immunology, 2022 - frontiersin.org
GS-441524, an RNA‐dependent RNA polymerase (RdRp) inhibitor, is a 1′-CN-substituted
adenine C-nucleoside analog with broad-spectrum antiviral activity. However, the low oral …

[HTML][HTML] The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to …

RP Joyce, VW Hu, J Wang - Medicinal Chemistry Research, 2022 - Springer
The rapid development of effective vaccines to combat the SARS-CoV-2 virus has been an
effective counter measure to decrease hospitalization and the mortality rate in many …

Recent progress of antiviral therapy for coronavirus disease 2019

M Zhao, J Zhang, H Li, Z Luo, J Ye, Y Xu… - European journal of …, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic has become a global public
health crisis, for which antiviral treatments are considered mainstream therapeutic …

[HTML][HTML] Potential RNA-dependent RNA polymerase inhibitors as prospective therapeutics against SARS-CoV-2

R Pokhrel, P Chapagain… - Journal of medical …, 2020 - microbiologyresearch.org
Introduction. The emergence of SARS-CoV-2 has taken humanity off guard. Following an
outbreak of SARS-CoV in 2002, and MERS-CoV about 10 years later, SARS-CoV-2 is the …

[HTML][HTML] Efficacy and safety of Molnupiravir in COVID-19 patients: A systematic review

KR Mali, M Eerike, GM Raj, D Bisoi… - Irish Journal of Medical …, 2023 - Springer
Background Molnupiravir is an oral antiviral drug that received Emergency Use
Authorization in three countries for the treatment of mild COVID-19. The aim of this …

COVID-19 therapeutics for nonhospitalized patients

RT Gandhi, PN Malani, C Del Rio - Jama, 2022 - jamanetwork.com
Substantial progresshas been made in therapeutics for nonhospitalizedpatientswithCOVID-
19, butsupplyofand access to treatment remain limited. This Viewpoint summarizes currently …