The serine/threonine kinase DYRK1A has been implicated in regulation of a variety of
cellular processes associated with cancer progression, including cell cycle control, DNA …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a member of an
evolutionarily conserved family of protein kinases that belongs to the CMGC group of …

Various types of cancers (including gliomas, melanomas, and esophageal, pancreas and
non-small-cell lung cancers) display intrinsic resistance to pro-apoptotic stimuli, such as …

Protein kinases are one of the most studied drug targets in current pharmacological
research, as evidenced by the vast number of kinase-targeting agents enrolled in active …

The kinase DYRK1A is an attractive target for drug discovery programs due to its implication
in multiple diseases. Through a fragment screen, we identified a simple biaryl compound …

Introduction: Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a
eukaryotic serine-threonine protein kinase belonging to the CMGC group. DYRK1A …

DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is an evolutionarily
conserved protein kinase and the most studied member of the Dual-specificity tyrosine …

Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …

The function of many protein kinases is controlled by the phosphorylation of a critical
tyrosine residue in the activation loop. Dual specificity tyrosine‐phosphorylation‐regulated …