Introduction Premature senescence, a terminal cell-cycle arrest condition of viable cells in
response to acute cellular stresses such as oncogenic activation or DNA-damaging …

Lesion-based targeting strategies underlie cancer precision medicine. However, biological
principles–such as cellular senescence–remain difficult to implement in molecularly …

Abstract Background Histone modification H4K20me3 and its methyltransferase SUV420H2
have been implicated in suppression of tumorigenesis. The underlying mechanism is …

Cellular senescence is a tumor-suppressive mechanism blocking cell proliferation in
response to stress. However, recent evidence suggests that senescent tumor cells can re …

Activated oncogenes and anticancer chemotherapy induce cellular senescence, a terminal
growth arrest of viable cells characterized by S-phase entry-blocking histone 3 lysine 9 …

Oncogene-induced senescence is an important barrier during melanomagenesis. In this
issue of Cancer Cell, Yu et al. show how elevated expression of structurally unrelated H3K9 …

Oncogene-induced senescence, eg, in melanocytic nevi, terminates the expansion of pre-
malignant cells via transcriptional silencing of proliferation-related genes due to decoration …

Senescence is a state of permanent proliferation arrest that normal cells undergo in
response to shortened telomeres, oncogenic activation and other sources of cellular stress …

Epigenetic program is a molecular basis of cellular identity and functions. We have shown
the transcriptome (Cancer Cell, 2012) and the underlying histone methylation patterns …

Acute induction of oncogenic Ras provokes cellular senescence involving the
retinoblastoma (Rb) pathway, but the tumour suppressive potential of senescence in vivo …