Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting
Synthesis, physicochemical behavior, tumor accumulation and preliminary anticancer
activity of a new biodegradable graft copolymer–doxorubicin (DOX) conjugates designed for …
activity of a new biodegradable graft copolymer–doxorubicin (DOX) conjugates designed for …
Properties of HPMA copolymer–doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification
Various conjugates of anticancer drug doxorubicin (DOX) covalently attached via
hydrolytically degradable hydrazone bond to water-soluble N-(2-hydroxypropyl) …
hydrolytically degradable hydrazone bond to water-soluble N-(2-hydroxypropyl) …
Preclinical evaluation of linear HPMA-doxorubicin conjugates with pH-sensitive drug release: efficacy, safety, and immunomodulating activity in murine model
Purpose In vivo efficacy and safety of HPMA-based copolymers armed with doxorubicin via
a spacer containing pH-sensitive linkage that can be prepared within a broad range of …
a spacer containing pH-sensitive linkage that can be prepared within a broad range of …
New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties
T Etrych, M Jelı́nková, B Řı́hová, K Ulbrich - Journal of Controlled Release, 2001 - Elsevier
In this paper we describe the synthesis, physico-chemical characteristics and results of tests
of biological activity of polymer drugs based on conjugates of anti-cancer drug doxorubicin …
of biological activity of polymer drugs based on conjugates of anti-cancer drug doxorubicin …
Preclinical evaluation of polymer-bound doxorubicin
R Duncan, LW Seymour, KB O'Hare… - Journal of controlled …, 1992 - Elsevier
Abstract N-(2-Hydroxypropyl) methacrylamide (HPMA) copolymers (Mw approximately 20
000) were synthesised to contain doxorubicin (DOX)(approximately 7 wt%) attached to the …
000) were synthesised to contain doxorubicin (DOX)(approximately 7 wt%) attached to the …
HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity
T Etrych, V Šubr, J Strohalm, M Šírová, B Říhová… - Journal of controlled …, 2012 - Elsevier
The molecular weight and molecular architecture of soluble polymer drug carriers
significantly influence the biodistribution and anti‐tumour activities of their doxorubicin …
significantly influence the biodistribution and anti‐tumour activities of their doxorubicin …
HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity
Data on the synthesis, physicochemical characterisation and in vitro and in vivo biological
properties of the new, nontargeted or antibody-targeted polymer–doxorubicin conjugates …
properties of the new, nontargeted or antibody-targeted polymer–doxorubicin conjugates …
Novel star HPMA-based polymer conjugates for passive targeting to solid tumors
Novel star polymer-doxorubicin conjugates designed for passive tumor targeting have been
developed and their potential for treatment of cancer has been investigated. In the present …
developed and their potential for treatment of cancer has been investigated. In the present …
Binding and cytotoxicity of HPMA copolymer conjugates to lymphocytes mediated by receptor-binding epitopes
A Tang, P Kopečková, J Kopeček - Pharmaceutical research, 2003 - Springer
Purpose. Studies on the recognition of epitopes presented on a template peptide showed
the potential of nonapeptide-related sequences to act as biorecognition sites for the B-cell …
the potential of nonapeptide-related sequences to act as biorecognition sites for the B-cell …
Antibody-targeted polymer–doxorubicin conjugates with pH-controlled activation
The paper is dealing with the synthesis and properties of new non-targeted or antibody-
targeted polymer drug conjugates, bearing doxorubicin (DOX) attached via a spacer …
targeted polymer drug conjugates, bearing doxorubicin (DOX) attached via a spacer …