The activation of T lymphocytes requires their stimulation via clonotypic antigen receptors as
well as nonantigen-specific costimulators, the best defined of which is the cytokine …

We examined the role of IL 2 and IL 2 receptors in human T lymphocyte proliferation induced
by neuraminidase and galactose oxidase (NAGO)-treated autologous macrophages. T …

The macrophage-derived product, interleukin 1 (IL 1) is thought to play an important
regulatory role in the proliferation of T lymphocytes; however, its mechanism of action is …

The role of interleukin 4 (IL-4)(previously called B-cell stimulatory factor 1) in the response of
T helper (TH) cells to antigen presented by antigen-specific B cells or splenic adherent cells …

IL-9 is produced in vitro by activated CD4+ T cell lines of the Th2 subtype and by naive
CD4+ T cells. Here we show that T cell lines stimulated with Con A in the presence of …

Naive T cells in the periphery mainly secrete interleukin (IL) 2 upon activation. After
stimulation in the presence of appropriate costimulators, both CD4+ and CD8+ T cells …

The antigen-specific activation of T cells is dependent upon two distinct but interdependent
macrophage signals. Macrophages are required to bin^, process, and present antigens in …

Most studies have shown that interleukin-1 (IL-1) acts as a helper or co-stimulator in T-
lymphocyte activation and proliferation by mitogens or antigens. We describe here a stable …

Recently, we reported the isolation of a cDNA clone that encodes a polypeptide which has B
cell and T cell growth factor activities. The amino acid sequence of this polypeptide deduced …

Purified T cells can be induced to proliferate and to produce the autocrine growth factor IL-2
with mAb to the TCR and costimulatory cytokines. In a previous report we demonstrated that …