Recent studies have demonstrated that in peripheral lymphoid tissues of normal mice and
healthy humans, 1% to 5% of αβ T-cell receptor–positive (TCR+) T cells are CD4 …

Double-negative T (DNT) cells are αβTCR+ CD3+ CD4− CD8− NK1. 1− cells that constitute
a small but significant proportion of the αβTCR+ T cells. Their developmental pathway and …

Recent studies have demonstrated that activated peripheral αβTCR+ CD3+ CD4− CD8−
NK1. 1−(double-negative, DN) regulatory T cells (Tregs) from both mice and humans are …

Double‐negative (DN) T cells are present at relatively low frequencies in human peripheral
blood, and are characterized as expressing the alpha‐beta or gamma‐delta T‐cell receptor …

The cellular origin of CD4− CD8−(double negative, DNT) TCR-α/β+ T cells remains
unknown. Available evidence indicates that they may derive from CD8+ T cells, but most …

Regulatory T cells (Tregs) play an important role in the maintenance of immune tolerance to
self‐antigens and are involved in modulating immune responses in autoimmunity, transplant …

Abstract CD4+/CD8+ DP thymocytes are a well-described T cell developmental stage within
the thymus. However, once differentiated, the CD4+ lineage or the CD8+ lineage is …

It has recently been shown that CD4+ CD25+ T cells are immunoregulatory T cells that
prevent CD4+ T-cell–mediated organ-specific autoimmune diseases. In this study, the …

TCR‐αβ+ double negative (DN) T cells (CD3+ TCR‐αβ+ CD4− CD8− NK1. 1− CD49b−)
represent a minor heterogeneous population in healthy humans and mice. These cells have …

The immune system contains natural regulatory T cells that control the magnitude of the
immune response during physiologic and pathologic conditions. Although this suppressive …