FLT3‐ITD mutations in acute myeloid leukaemia–molecular characteristics, distribution and numerical variation
C Engen, M Hellesøy, T Grob, A Al Hinai… - Molecular …, 2021 - Wiley Online Library
Recurrent somatic internal tandem duplications (ITD) in the FMS‐like tyrosine kinase 3
(FLT3) gene characterise approximately one third of patients with acute myeloid leukaemia …
(FLT3) gene characterise approximately one third of patients with acute myeloid leukaemia …
Patient‐specific analysis of FLT3 internal tandem duplications for the prognostication and monitoring of acute myeloid leukemia
J Schiller, I Praulich, C Krings Rocha… - European journal of …, 2012 - Wiley Online Library
Objectives Internal tandem duplications (ITD s) of the fms‐like tyrosine kinase 3 (FLT 3)
gene occur in 13–35% of patients with acute myeloid leukemia (AML). FLT 3‐ITD is …
gene occur in 13–35% of patients with acute myeloid leukemia (AML). FLT 3‐ITD is …
[HTML][HTML] Impact of FLT3-ITD mutational burden in 469 acute myeloid leukemia (AML) patients
Background: FLT3-ITD mutational status is a well known prognostic factor in AML patients.
However, its prognostic value in case of low mutational burden is currently under debate …
However, its prognostic value in case of low mutational burden is currently under debate …
[HTML][HTML] Clonal heterogeneity of FLT3-ITD detected by high-throughput amplicon sequencing correlates with adverse prognosis in acute myeloid leukemia
In acute myeloid leukemia (AML), internal tandem duplications (ITDs) of FLT3 are frequent
mutations associated with unfavorable prognosis. At diagnosis, the FLT3-ITD status is …
mutations associated with unfavorable prognosis. At diagnosis, the FLT3-ITD status is …
Impact of numerical variation, allele burden, mutation length and co-occurring mutations on the efficacy of tyrosine kinase inhibitors in newly diagnosed FLT3-mutant …
I Abou Dalle, A Ghorab, K Patel, X Wang… - Blood cancer …, 2020 - nature.com
FLT3-ITD mutations in newly diagnosed acute myeloid leukemia (AML) are associated with
worse overall survival (OS). FLT3-ITD diversity can further influence clinical outcomes …
worse overall survival (OS). FLT3-ITD diversity can further influence clinical outcomes …
[HTML][HTML] Prognostic impact of insertion site in acute myeloid leukemia (AML) with FLT3 internal tandem duplication: results from the ratify study (Alliance 10603)
FG Rücker, L Du, TJ Blätte, A Benner, J Krzykalla… - Blood, 2018 - Elsevier
Introduction: Internal tandem duplication of the FLT3 gene (FLT3-ITD), resulting in
duplication of 3 to more than hundreds of nucleotides, are present in approximately 25% of …
duplication of 3 to more than hundreds of nucleotides, are present in approximately 25% of …
Prognostic value of the mutation types and dynamics of FLT3‐ITD in acute myeloid leukemia
M Koo, IC Song, J Kim, GC Kwon… - European Journal of …, 2023 - Wiley Online Library
Objective The prognostic value of the mutation types and dynamics of FLT3‐ITD in acute
myeloid leukemia (AML) and other known factors were studied. Methods Initial and follow …
myeloid leukemia (AML) and other known factors were studied. Methods Initial and follow …
Prognostic significance of FLT3-ITD length in AML patients treated with intensive regimens
T Castaño-Bonilla, JM Alonso-Dominguez… - Scientific Reports, 2021 - nature.com
FLT3-ITD mutations are detected in approximately 25% of newly diagnosed adult acute
myeloid leukemia (AML) patients and confer an adverse prognosis. The FLT3-ITD allelic …
myeloid leukemia (AML) patients and confer an adverse prognosis. The FLT3-ITD allelic …
Medium-sized FLT3 internal tandem duplications confer worse prognosis than short and long duplications in a non-elderly acute myeloid leukemia cohort
M Koszarska, N Meggyesi, A Bors, A Batai… - Leukemia & …, 2014 - Taylor & Francis
Internal tandem duplications (ITDs) of the fms-like tyrosine kinase 3 (FLT3) gene occur in
about 25% of patients with adult acute myeloid leukemia (AML). The aim of our study was to …
about 25% of patients with adult acute myeloid leukemia (AML). The aim of our study was to …
FLT3-ITD allele frequency is an independent prognostic factor for poor outcome in FLT3-ITD–positive AML patients
NF Shafik, AD Darwish, RM Allam… - … Lymphoma Myeloma and …, 2021 - Elsevier
Background FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is a
molecular genetic alteration significantly affecting the clinical outcome in patients with acute …
molecular genetic alteration significantly affecting the clinical outcome in patients with acute …