Hepatobiliary excretion mediated by transporters, organic anion-transporting polypeptide
(OATP) 1B1 and multidrug resistance-associated protein (MRP) 2, is the major elimination …

This review illustrates the concept of a rate-determining process in the overall hepatic
elimination of anionic drugs that involves transporters in the uptake process. A kinetic study …

Purpose To develop physiologically based pharmacokinetic (PBPK) model to predict the
pharmacokinetics and drug-drug interactions (DDI) of pravastatin, using the in vitro transport …

Transporters govern drug movement into and out of tissues, thereby playing an important
role in drug disposition in plasma and to the site of action. The molecular cloning of such …

Elucidation of the rate-determining process in the overall hepatic elimination of drugs is
critical for predicting their intrinsic hepatic clearance and the impact of variation of …

Typically, pharmacokinetic–pharmacodynamic (PK/PD) models use plasma concentration
as the input that drives the PD model. However, interindividual variability in uptake …

The biliary excretion of pravastatin in normal rats and Eisai hyperbiliruminemic rats (EHBRs)
was examined in vivo and in vitro using bile canalicular membrane vesicles (CMVs). In vivo …

Previous studies have shown that lipid-lowering statins are transported by various ATP-
binding cassette (ABC) transporters. However, because of varying methods, it is difficult to …

Rosuvastatin is an HMG-CoA reductase inhibitor and one of the most hydrophilic among the
commercially available statins. It is efficiently accumulated in the liver and excreted into the …

Differences in the expression and function of the organic anion transporting polypeptide
(OATP) transporters contribute to interindividual variability in atorvastatin clearance …