The inhibition of acquired fear

I Izquierdo, M Cammarota, MRM Vianna… - Neurotoxicity …, 2004 - Springer
A conditioned stimulus (CS) associated with a fearsome unconditioned stimulus (US)
generates learned fear. Acquired fear is at the root of a variety of disorders, among which …

Pharmacological treatments that facilitate extinction of fear: relevance to psychotherapy

M Davis, KM Myers, J Chhatwal, KJ Ressler - NeuroRx, 2006 - Springer
A great deal is now known about the mechanisms of conditioned fear acquisition and
expression. More recently, the mechanisms of inhibition of conditioned fear have become …

The learning of fear extinction

C Furini, J Myskiw, I Izquierdo - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
Recent work on the extinction of fear-motivated learning places emphasis on its putative
circuitry and on its modulation. Extinction is the learned inhibition of retrieval of previously …

Fear memory

I Izquierdo, CRG Furini, JC Myskiw - Physiological reviews, 2016 - journals.physiology.org
Fear memory is the best-studied form of memory. It was thoroughly investigated in the past
60 years mostly using two classical conditioning procedures (contextual fear conditioning …

Evidence for recovery of fear following immediate extinction in rats and humans

D Schiller, CK Cain, NG Curley, JS Schwartz… - Learning & …, 2008 - learnmem.cshlp.org
Fear responses can be eliminated through extinction, a procedure involving the presentation
of fear-eliciting stimuli without aversive outcomes. Extinction is believed to be mediated by …

The promise of extinction research for the prevention and treatment of anxiety disorders

KC Anderson, TR Insel - Biological psychiatry, 2006 - biologicalpsychiatryjournal.com
Aconservative estimate indicates that almost 30% of the US population will be afflicted with
an anxiety disorder at some point in their lives, and preliminary data suggest that this risk is …

US habituation, like CS extinction, produces a decrement in conditioned fear responding that is NMDA dependent and subject to renewal and reinstatement

AB Storsve, GP McNally, R Richardson - Neurobiology of learning and …, 2010 - Elsevier
Just as fear can be learned, it can also be inhibited. The most common way of reducing
learned fear is through extinction, where the conditioned stimulus (CS) previously paired …

Evidence for the persistence of contextual fear memories following immediate extinction

GEB Archbold, ME Bouton… - European Journal of …, 2010 - Wiley Online Library
Evidence suggests that extinction, the suppression of a learned response to a Pavlovian
signal that is produced by exposure to the signal alone after conditioning, is a consequence …

“All we have to fear is fear itself”: Paradigms for reducing fear by preventing awareness of it.

P Siegel, BS Peterson - Psychological Bulletin, 2024 - psycnet.apa.org
Research on unconscious fear responses has recently been translated into experimental
paradigms for reducing fear that bypass conscious awareness of the phobic stimulus and …

Use of the ABA fear renewal paradigm to assess the effects of extinction with co-present fear inhibitors or excitors: Implications for theories of extinction and for treating …

BL Thomas, JJB Ayres - Learning and Motivation, 2004 - Elsevier
In four experiments using albino rats in an ABA fear renewal paradigm, we studied
conditioned fear in the A test context following extinction in Context B. Conditioned …