Homogeneous detection of nucleic acids based upon the light scattering properties of silver-coated nanoparticle probes

X Xu, DG Georganopoulou, HD Hill… - Analytical …, 2007 - ACS Publications
Herein we report the development of a simple, rapid, homogeneous, and sensitive detection
system for DNA based on the scattering properties of silver-amplified gold nanoparticle …

Colorimetric detection of DNA using unmodified metallic nanoparticles and peptide nucleic acid probes

R Kanjanawarut, X Su - Analytical chemistry, 2009 - ACS Publications
We have developed a colorimetric assay for DNA detection based on the aggregation of
unmodified metallic nanoparticles. Charge neutral peptide nucleic acids (PNA) are used as …

Silver-enhanced colloidal gold electrochemical stripping detection of DNA hybridization

J Wang, R Polsky, D Xu - Langmuir, 2001 - ACS Publications
We report on a novel method for detecting DNA hybridization, based on the precipitation of
silver on gold nanoparticle tags and a subsequent electrochemical stripping detection of the …

DNA sequence detection using selective fluorescence quenching of tagged oligonucleotide probes by gold nanoparticles

H Li, LJ Rothberg - Analytical chemistry, 2004 - ACS Publications
Simple, fast, economical, and sensitive detection of specific DNA sequences is crucial to
pathogen detection and biomedical research. We have designed a novel fluorescent assay …

A two-color-change, nanoparticle-based method for DNA detection

YC Cao, R Jin, CS Thaxton, CA Mirkin - Talanta, 2005 - Elsevier
Herein, we describe the detailed synthesis of Ag/Au core-shell nanoparticles, the surface-
functionalization of these particles with thiolated oligonucleotides, and their subsequent use …

Gold nanoparticle-based detection of genomic DNA targets on microarrays using a novel optical detection system

JJ Storhoff, SS Marla, P Bao, S Hagenow… - Biosensors and …, 2004 - Elsevier
The development of a nanoparticle-based detection methodology for sensitive and specific
DNA-based diagnostic applications is described. The technology utilizes gold nanoparticles …

Simple, rapid, homogeneous oligonucleotides colorimetric detection based on non-aggregated gold nanoparticles

Y Liu, Z Wu, G Zhou, Z He, X Zhou, A Shen… - Chemical …, 2012 - pubs.rsc.org
Simple, rapid, homogeneous oligonucleotides colorimetric detection based on non-aggregated
gold nanoparticles - Chemical Communications (RSC Publishing) DOI:10.1039/C2CC16741G …

UV–visible spectroscopy-based quantification of unlabeled DNA bound to gold nanoparticles

BL Baldock, JE Hutchison - Analytical chemistry, 2016 - ACS Publications
DNA-functionalized gold nanoparticles have been increasingly applied as sensitive and
selective analytical probes and biosensors. The DNA ligands bound to a nanoparticle …

[HTML][HTML] Gold nanoparticle aggregation for quantification of oligonucleotides: optimization and increased dynamic range

MS Cordray, M Amdahl, RR Richards-Kortum - Analytical biochemistry, 2012 - Elsevier
A variety of assays have been proposed to detect small quantities of nucleic acids at the
point of care. One approach relies on target-induced aggregation of gold nanoparticles …

Functionalized gold nanoparticles for ultrasensitive DNA detection

LM Zanoli, R D'Agata, G Spoto - Analytical and bioanalytical chemistry, 2012 - Springer
A major challenge in the area of DNA detection is the development of rapid methods that do
not require polymerase chain reaction (PCR) amplification of the genetic sample. The PCR …