Mounting evidence supports the hypothesis that spinal microglia modulate the development
and maintenance of some chronic pain states. Here we examined the role of spinal …

The pharmacological attenuation of glial activation represents a novel approach for
controlling neuropathic pain, but the role of microglial and astroglial cells is not well …

Microglia are the resident macrophages in the central nervous system (CNS). Any insult to
the CNS homeostasis will induce a rapid change in microglia morphology, gene expression …

Glial activation is a typical response of the central nervous system to nerve injury. In the
current investigation, we characterized the temporal and spatial pattern of glial proliferation …

Peripheral nerve injuries that provoke neuropathic pain are associated with microglial
activation in the spinal cord. We have investigated the characteristics of spinal microglial …

The role of microglia and their contribution to the development and maintenance of pain
states has emerged as an attractive field of study. Sensitization of central nociceptors and …

There is increasing evidence that spinal glial cells play an important role in chronic pain
states. However, so far no data on the role of microglia in muscle pain are available. The aim …

We compared the effects of peripheral Freund's Complete Adjuvant (CFA) and formalin
injection on spinal microglia activation. Both qualitative and quantitative analyses showed …

Peripheral nerve injury commonly leads to neuropathic pain states fostered, in part, by
neuroimmunologic events. We used two models of neuropathic pain (L5 spinal nerve …

Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic
central pain, which can be refractory to conventional treatment approaches. It has been …