Gating of nicotinic ACh receptors: latest insights into ligand binding and function

JL Yakel - The Journal of Physiology, 2010 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs) are in the superfamily of cys‐loop receptors, and
are widely expressed in the nervous system where they participate in a variety of …

Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening

EA Gay, JL Yakel - The Journal of physiology, 2007 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs) are in the superfamily of Cys‐loop ligand‐gated
ion channels, and are pentameric assemblies of five subunits, with each subunit arranged …

The wonderland of neuronal nicotinic acetylcholine receptors

D Bertrand, AV Terry Jr - Biochemical pharmacology, 2018 - Elsevier
Nearly 30 years of experimental evidence supports the argument that ligands of nicotinic
acetylcholine receptors (nAChRs) have potential as therapeutic agents. However, as in the …

Recent advances in understanding the structure of nicotinic acetylcholine receptors

M Zouridakis, P Zisimopoulou, K Poulas… - IUBMB life, 2009 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs), members of the Cys‐loop ligand‐gated ion
channels (LGICs) superfamily, are involved in signal transduction upon binding of the …

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins

A Karlin, MH Akabas - Neuron, 1995 - Elsevier
The nicotinic acetylcholine (ACh) receptors and the other neurotransmitter-gated ion
channels have key roles in fast synaptic transmission throughout the nervous system. These …

Nicotinic receptors at the amino acid level

PJ Corringer, NL Novère… - Annual review of …, 2000 - annualreviews.org
nAChRs are pentameric transmembrane proteins into the superfamily of ligand-gated ion
channels that includes the 5HT3, glycine, GABAA, and GABAC receptors. Electron …

Opened by a twist: a gating mechanism for the nicotinic acetylcholine receptor

A Taly - European Biophysics Journal, 2007 - Springer
Nicotinic acetylcholine receptors (nAChRs) play a central role in intercellular
communications in the brain and at the neuromuscular junction. They are involved in …

Positive and negative modulation of nicotinic receptors

HR Arias - Advances in protein chemistry and structural biology, 2010 - Elsevier
Nicotinic acetylcholine receptors (AChRs) are one of the best characterized ion channels
from the Cys-loop receptor superfamily. The study of acetylcholine binding proteins and …

The nicotinic acetylcholine receptor: molecular architecture of a ligand-regulated ion channel

JP Changeux, J Giraudat, M Dennis - Trends in Pharmacological Sciences, 1987 - cell.com
The nAChR is a membrane-bound allosteric protein which carries several categories of
topologically distinct binding sites and mediates interactions between these sites by …

Probing the effects of residues located outside the agonist binding site on drug-receptor selectivity in the nicotinic receptor

NL Puskar, HA Lester, DA Dougherty - ACS chemical biology, 2012 - ACS Publications
The nicotinic acetylcholine receptors (nAChRs) are a family of closely related but
pharmacologically distinct neurotransmitter-gated ion channels. They are therapeutic targets …