EA Gay, JL Yakel - The Journal of physiology, 2007 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs) are in the superfamily of Cys‐loop ligand‐gated ion channels, and are pentameric assemblies of five subunits, with each subunit arranged …
D Bertrand, AV Terry Jr - Biochemical pharmacology, 2018 - Elsevier
Nearly 30 years of experimental evidence supports the argument that ligands of nicotinic acetylcholine receptors (nAChRs) have potential as therapeutic agents. However, as in the …
M Zouridakis, P Zisimopoulou, K Poulas… - IUBMB life, 2009 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs), members of the Cys‐loop ligand‐gated ion channels (LGICs) superfamily, are involved in signal transduction upon binding of the …
The nicotinic acetylcholine (ACh) receptors and the other neurotransmitter-gated ion channels have key roles in fast synaptic transmission throughout the nervous system. These …
nAChRs are pentameric transmembrane proteins into the superfamily of ligand-gated ion channels that includes the 5HT3, glycine, GABAA, and GABAC receptors. Electron …
A Taly - European Biophysics Journal, 2007 - Springer
Nicotinic acetylcholine receptors (nAChRs) play a central role in intercellular communications in the brain and at the neuromuscular junction. They are involved in …
HR Arias - Advances in protein chemistry and structural biology, 2010 - Elsevier
Nicotinic acetylcholine receptors (AChRs) are one of the best characterized ion channels from the Cys-loop receptor superfamily. The study of acetylcholine binding proteins and …
JP Changeux, J Giraudat, M Dennis - Trends in Pharmacological Sciences, 1987 - cell.com
The nAChR is a membrane-bound allosteric protein which carries several categories of topologically distinct binding sites and mediates interactions between these sites by …
NL Puskar, HA Lester, DA Dougherty - ACS chemical biology, 2012 - ACS Publications
The nicotinic acetylcholine receptors (nAChRs) are a family of closely related but pharmacologically distinct neurotransmitter-gated ion channels. They are therapeutic targets …