Genetic variant associations and advances in research technologies are generating an
unprecedented volume of genomic data. Whole-genome sequencing will introduce even …

Genomic science and associated technologies are facilitating an unprecedented rate of
discovery of novel insights into the relationship between human genetic variation and …

Bridging the gap between gene discovery and our ability to use genetic information to
benefit health requires population-based knowledge about the contribution of common gene …

Although still in the early stages of development, the advent of fast, high-output, and cost-
effective next-generation DNA sequencing technology is moving precision medicine into …

As we look to a time when whole-genome sequencing is integrated into patient care, it is
possible to anticipate a number of ethical challenges that will need to be addressed. The …

Informed consent, the process of gathering autonomous authorization for a medical
intervention or medical research participation, is a fundamental component of medical …

This article assesses the adequacy of informed consent to clinical genetic testing laws
based on an examination of 15 states with institutions that had been involved in a National …

Research on the use of genome and exome sequencing for diagnosis, identification of
potential therapies, precision prescribing of pharmaceuticals, and identification of disease …

The falling cost of sequencing means that we are rapidly approaching an era in which
access to personalized genomic information is likely to be widespread. Here, four experts …

The lack of diversity of populations included in genomics databases is an important inhibitor
of genomic discovery from bench to bedside. One way to increase the diversity of …