[HTML][HTML] New insight into neurological degeneration: Inflammatory cytokines and blood–brain barrier

J Yang, M Ran, H Li, Y Lin, K Ma, Y Yang… - Frontiers in molecular …, 2022 - frontiersin.org
Neurological degeneration after neuroinflammation, such as that resulting from Alzheimer's
disease (AD), stroke, multiple sclerosis (MS), and post-traumatic brain injury (TBI), is …

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

MD Sweeney, AP Sagare, BV Zlokovic - Nature Reviews Neurology, 2018 - nature.com
The blood–brain barrier (BBB) is a continuous endothelial membrane within brain
microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells …

[HTML][HTML] Blood-brain barrier dysfunction amplifies the development of neuroinflammation: understanding of cellular events in brain microvascular endothelial cells for …

F Takata, S Nakagawa, J Matsumoto… - Frontiers in cellular …, 2021 - frontiersin.org
Neuroinflammation is involved in the onset or progression of various neurodegenerative
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …

The role of the blood brain barrier in neurodegenerative disorders and their treatment

AM Palmer - Journal of Alzheimer's Disease, 2011 - content.iospress.com
Neurodegenerative disorders represent a major medical challenge that is set to increase
substantially in the decades ahead with the massive increase in the number of people in the …

[HTML][HTML] Neuroinflammation induces neurodegeneration

D Kempuraj, R Thangavel, PA Natteru… - Journal of neurology …, 2016 - ncbi.nlm.nih.gov
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
and Multiple Sclerosis (MS) are characterized by neuronal degeneration and neuronal …

[HTML][HTML] Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy

S Takeda, N Sato, R Morishita - Frontiers in aging neuroscience, 2014 - frontiersin.org
The incidence of dementia is increasing at an alarming rate, and has become a major public
health concern. Alzheimer disease (AD) is the most common form of dementia and is …

The blood–brain barrier in neurodegenerative disease: a rhetorical perspective

PM Carvey, B Hendey… - Journal of …, 2009 - Wiley Online Library
Recent studies suggest that the function of the blood–brain barrier (BBB) is not static under
normal physiologic conditions and is likely altered in neurodegenerative disease. Prevailing …

[HTML][HTML] The blood-brain barrier in Alzheimer's disease

E Zenaro, G Piacentino, G Constantin - Neurobiology of disease, 2017 - Elsevier
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by the
pathological accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles …

[HTML][HTML] Addressing blood–brain barrier impairment in Alzheimer's disease

C Sharma, H Woo, SR Kim - Biomedicines, 2022 - mdpi.com
The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the brain tissue. It facilitates communication while separating the …

The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases

F Zipp, O Aktas - Trends in neurosciences, 2006 - cell.com
Classical knowledge distinguishes between inflammatory and non-inflammatory diseases of
the brain. Either the immune system acts on the CNS and initiates a damage cascade, as in …