A precise and dynamic immune response is pivotal for maintaining defense against
pathogens, cellular homeostasis, and tissue repair following injury. Dysregulated immune …

Patients with diabetes suffer the higher risk of dementia and the underlying pathological
mechanism of cognitive dysfunction in diabetes is not fully understood. In this study, we …

Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease (AD),
Parkinson's disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis …

Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide,
and has emerged as a critical risk factor for multiple neurodegenerative diseases …

Significance: Accumulating evidence suggests that inflammation is a major contributor in the
pathogenesis of several highly prevalent, but also rare, neurological diseases. In particular …

Central nervous system (CNS) accumulation of fibrillary deposits made of Amyloid β (A β),
hyperphosphorylated Tau or α-synuclein (α-syn), present either alone or in the form of mixed …

Vascular cognitive impairment and dementia (VCID) is a major heterogeneous brain
disease caused by multiple factors, and it is the second most common type of dementia in …

The cerebrovascular system is not only inert bystandard that support the metabolic demands
of the brain but also elicit the barrier functions against risk factors mediated neurovascular …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

For a long time the brain has been considered an immune-privileged site due to a muted
inflammatory response and the presence of protective brain barriers. It is now recognized …