Brain injury–mediated neuroinflammatory response and Alzheimer's disease

D Kempuraj, ME Ahmed, GP Selvakumar… - The …, 2020 - journals.sagepub.com
Traumatic brain injury (TBI) is a major health problem in the United States, which affects
about 1.7 million people each year. Glial cells, T-cells, and mast cells perform specific …

[HTML][HTML] Brain injury, neuroinflammation and Alzheimer's disease

JJ Breunig, MV Guillot-Sestier, T Town - Frontiers in aging …, 2013 - frontiersin.org
With as many as 300,000 United States troops in Iraq and Afghanistan having suffered head
injuries (Miller,), traumatic brain injury (TBI) has garnered much recent attention. While the …

[HTML][HTML] Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease

MT Jeon, KS Kim, ES Kim, S Lee, J Kim, HS Hoe… - Ageing research …, 2021 - Elsevier
The responses of central nervous system (CNS) cells such as neurons and glia in
neurodegenerative diseases (NDs) suggest that regulation of neuronal and glial functions …

[HTML][HTML] Neuroinflammation as a key driver of secondary neurodegeneration following stroke?

SM Stuckey, LK Ong, LE Collins-Praino… - International Journal of …, 2021 - mdpi.com
Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

[HTML][HTML] Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?

CR Balistreri, R Monastero - Brain sciences, 2023 - mdpi.com
The term “neuroinflammation” defines the typical inflammatory response of the brain closely
related to the onset of many neurodegenerative diseases (NDs). Neuroinflammation is well …

[HTML][HTML] Blood–Brain Barrier Breakdown in Alzheimer's Disease: Mechanisms and Targeted Strategies

AE Alkhalifa, NF Al-Ghraiybah, J Odum… - International Journal of …, 2023 - mdpi.com
The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …

[HTML][HTML] Dysfunction of the blood-brain barrier—a key step in neurodegeneration and dementia

CR Noe, M Noe-Letschnig, P Handschuh… - Frontiers in aging …, 2020 - frontiersin.org
The vascular endothelium in the brain is an essential part of the blood-brain-barrier (BBB)
because of its very tight structure to secure a functional and molecular separation of the …

Aging, the metabolic syndrome, and ischemic stroke: redefining the approach for studying the blood–brain barrier in a complex neurological disease

BP Lucke-Wold, AF Logsdon, RC Turner… - Advances in …, 2014 - Elsevier
The blood–brain barrier (BBB) has many important functions in maintaining the brain's
immune-privileged status. Endothelial cells, astrocytes, and pericytes have important roles in …

Oxidative Stress‐Mediated Blood‐Brain Barrier (BBB) Disruption in Neurological Diseases

K Song, Y Li, H Zhang, N An, Y Wei… - Oxidative medicine …, 2020 - Wiley Online Library
The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

Blood-brain barrier dysfunction as a potential therapeutic target for neurodegenerative disorders

A Uprety, Y Kang, SY Kim - Archives of pharmacal research, 2021 - Springer
The blood-brain barrier (BBB) is composed of specific tight junction proteins and
transporters expressed on the lining of endothelial cells of the vasculature in the brain. The …