Summary Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract
infection, however, a subset of patients progress to severe disease and respiratory failure …

Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …

The mechanisms underlying the immune remodeling and severity response in coronavirus
disease 2019 (COVID-19) are yet to be fully elucidated. Our comprehensive integrative …

Mechanisms of neutrophil involvement in severe coronavirus disease 2019 (COVID-19)
remain incompletely understood. Here, we collect longitudinal blood samples from 306 …

Although critical illness has been associated with SARS-CoV-2–induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …

COVID-19 pathogenesis is associated with an exaggerated immune response. However, the
specific cellular mediators and inflammatory components driving diverse clinical disease …

After more than one year since the COVID-19 outbreak, patients with severe disease still
constitute the bottleneck of the pandemic management. Aberrant inflammatory responses …

Since the beginning of the SARS-CoV-2 pandemic, COVID-19 appeared as a unique
disease with unconventional tissue and systemic immune features. Here we show a COVID …

Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …

Recent studies have demonstrated immunologic dysfunction in severely ill coronavirus
disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to …