The value of identifying women with an inherited predisposition to epithelial ovarian cancer
has become readily apparent with the identification of the BRCA1, and BRCA2 genes …

The value of identifying women with an inherited predisposition to ovarian cancer has
become readily apparent with the identification of the BRCA1 and BRCA2 genes. Women …

A total of 283 epithelial ovarian cancer families from the United Kingdom (UK) and the
United States (US) were screened for coding sequence changes and large genomic …

To establish the contribution of germline BRCA1 and BRCA2 mutations to familial ovarian
cancer, we have analyzed both genes in DNA samples obtained from an affected individual …

Genetic testing for susceptibility to ovarian cancer is rapidly becoming integrated into the
clinical practice of oncology. Genetic testing for BRCA1 and BRCA2 is now recommended to …

The Nordic countries have the highest incidences of ovarian cancer in the world (around 15
cases per 100,000 women). We have conducted a review of the recent literature with focus …

Families with multiple cases of ovarian cancer have long been observed, and in the past
prophylactic oophorectomy has been advocated for women with a history of ovarian cancer …

Germline mutations of the BRCA1 and BRCA2 genes confer a high life-time risk of ovarian
cancer. They represent the most significant and well characterised genetic risk factors so far …

Objectives. The aim of the study was to determine the prevalence of BRCA1 and BRCA2
germline mutations among ovarian cancer patients ascertained to have a family history of …

Background Approximately one out of every 10 ovarian cancers is caused by inherited
mutations in identified genes. The characterization of hereditary ovarian cancer as an …