Approximately 10% of all epithelial ovarian carcinoma cases are associated with inheritance
of an autosomal-dominant genetic mutation conferring a predisposition to cancer with …

We analyzed the clinical features of 25 ovarian cancer patients who were associated with
germ-line mutations of BRCA1 from four site-specific ovarian cancer families and seven …

The natural history of hereditary and BRCA1-and BRCA2-associated epithelial ovarian
cancer may differ from that of sporadic disease. The purpose of this study was to compare …

While there are many reports in the literature of mutation testing of BRCA1 and BRCA2 in
breast/ovarian cancer families, the question of which type of ovarian cancers are relevant …

Purpose: Inherited ovarian cancer carries a serious prognosis. Prophylactic oophorectomy
has been advocated. The degree to which inherited ovarian cancer is restricted to BRCA …

Germ-line mutations in the BRCA1 and BRCA2 genes confer a predisposition to breast as
well as ovarian carcinoma. Except for loss of the respective wild-type allele, somatic genetic …

Background: Family history is the strongest risk factor for ovarian cancer. Recent evidence
suggests that unidentified BRCA1/2 variations or other genetic events may contribute to …

More than one‐fifth of ovarian tumors have hereditary susceptibility and, in about 65–85% of
these cases, the genetic abnormality is a germline mutation in BRCA genes. Nevertheless …

ContextMost hereditary ovarian cancers are associated with germline mutations in BRCA1
or BRCA2. Attempts to define the clinical significance of BRCA mutation status in ovarian …

BACKGROUND The high mortality associated with ovarian carcinoma is largely a reflection
of the inability to diagnose the disease at an early stage; the identification of a histologic …