Rh-catalyzed hydroformylation-initiated bicyclization: Construction of azabicyclic systems

WH Chiou, KH Hsu, WW Huang - ACS omega, 2020 - ACS Publications
Here, we describe the recent progress toward construction of 1-azabicyclic structures using
a domino hydroformylation double cyclization strategy of an amide bearing the trisubstituted …

Rhodium‐Catalyzed Domino Hydroformylation/Double‐Cyclization Reaction of Arylacetylenecarboxamides: Diastereoselectivity Studies and Application in the …

JC Tsai, YH Lin, GT Chen, YK Gao… - Chemistry–An Asian …, 2018 - Wiley Online Library
A domino method for the rapid syntheses of 1‐azabicyclo [xy 0] alkane scaffolds, such as
indolizidines, quinolizidines, decahydropyridoazepines, and their derivatives, has been …

Stereodivergent Synthesis of Alkaloid (±)-223A and (±)-6-epi-223A via Rh-Catalyzed Hydroformylation Double Cyclization

WW Huang, JT Cheng, WT Hsiao… - The Journal of Organic …, 2024 - ACS Publications
A stereodivergent approach toward total syntheses of Dendrobatid alkaloids 223A and 6-epi-
223A is described. The approach features a concise construction of an indolizidine skeleton …

Hydroformylation of homoallylic azides: A rapid approach toward alkaloids

T Spangenberg, B Breit, A Mann - Organic Letters, 2009 - ACS Publications
Hydroformylation of Homoallylic Azides: A Rapid Approach toward Alkaloids | Organic Letters
ACS ACS Publications C&EN CAS Find my institution Log In Organic Letters ACS Publications …

Fully atom-economic access to spiro-cyclic skeletons through photoredox-induced hydrogen transfer/Giese addition/dearomative cyclization/protonation cascade

G Zeng, H Luo, K Jiang, J Cai, B Yin - Organic Chemistry Frontiers, 2024 - pubs.rsc.org
Herein, we report a fully atom-economic and highly step-economic cascade dearomatization
with non-activated phenyl and other hetero-aryl rings for access to aniline-tethered spiro …

Azabicycles construction: the transannular ring contraction with N-protected nucleophiles

A Rizzo, SR Harutyunyan - Organic & Biomolecular Chemistry, 2014 - pubs.rsc.org
Synthetic strategies are one of the most critical factors for the success of a synthetic
campaign, but most importantly they are crucial for the economy and the efficiency of the …

Alkyne-mediated domino hydroformylation/double cyclization: mechanistic insight and synthesis of (±)-tashiromine

WH Chiou, YH Lin, GT Chen, YK Gao… - Chemical …, 2011 - pubs.rsc.org
A novel domino reaction, alkyne-mediated domino hydroformylation/double cyclization, has
been developed for rapid preparation of indolizidine type alkaloids. DFT calculations were …

Domino Rh-catalyzed hydroformylation–double cyclization of o-amino cinnamyl derivatives: applications to the formal total syntheses of physostigmine and …

WH Chiou, CL Kao, JC Tsai, YM Chang - Chemical Communications, 2013 - pubs.rsc.org
A parallel, versatile and efficient route to synthesis of pyrrolidinoindoline and
tetrahydrofuranoindoline alkaloids from cinnamyl derivatives has been developed, featuring …

Regioselective Synthesis of the Tetrahydrocarbazole Core of Akuammiline Alkaloids via Palladium-Catalyzed Intramolecular Arylation Reaction

NMR Vampugani, AB Shelke, PB Singh… - The Journal of …, 2024 - ACS Publications
Tetrahydrocarbazole is the central core for several biologically active alkaloids, and
regioselective synthesis of this core is a challenging task. Herein, we report an efficient …

A general catalytic reaction sequence to access alkaloid-inspired indole polycycles

A Danda, K Kumar, H Waldmann - Chemical Communications, 2015 - pubs.rsc.org
A catalytic two-step reaction sequence was developed to access a range of complex
heterocyclic frameworks based on biorelevant indole/oxindole scaffolds. The reaction …