The pathogenic processes driving Alzheimer's disease (AD) are complex. An incomplete
understanding of underlying disease mechanisms has presented insurmountable obstacles …

The recent FDA-approval for amyloid lowering therapies reflects an unwavering commitment
from the Alzheimer's disease (AD) research community to identify treatments for this leading …

Aging is the major predictor for developing multiple neurodegenerative diseases, including
Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells …

Cellular senescence is a potential tumor-suppressive mechanism that generally results in an
irreversible cell cycle arrest. Senescent cells accumulate with age and actively secrete …

Aging is inevitable. Along with reduced ability to maintain the homeostasis of various
biological processes, aging gradually deteriorates overall health. Extensive research on the …

Cellular senescence is a state of permanent cell-cycle arrest. Early in life, senescence has a
physiologic role in tumor suppression and wound healing. However, gradually, as these …

Cellular senescence is a biological aging hallmark that plays a key role in the development
of neurodegenerative diseases. Clinical trials are currently underway to evaluate the …

Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Preclinical studies indicate an age-associated accumulation of senescent cells across
multiple organ systems. Emerging evidence suggests that tau protein accumulation, which …

Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …