[HTML][HTML] From GWAS to function: using functional genomics to identify the mechanisms underlying complex diseases
E Cano-Gamez, G Trynka - Frontiers in genetics, 2020 - frontiersin.org
Genome-wide association studies (GWAS) have successfully mapped thousands of loci
associated with complex traits. These associations could reveal the molecular mechanisms …
associated with complex traits. These associations could reveal the molecular mechanisms …
[PDF][PDF] Beyond GWASs: illuminating the dark road from association to function
Genome-wide association studies (GWASs) have enabled the discovery of common genetic
variation contributing to normal and pathological traits and clinical drug responses, but …
variation contributing to normal and pathological traits and clinical drug responses, but …
[HTML][HTML] GWAS and drug targets
C Cao, J Moult - BMC genomics, 2014 - Springer
Background Genome wide association studies (GWAS) have revealed a large number of
links between genome variation and complex disease. Among other benefits, it is expected …
links between genome variation and complex disease. Among other benefits, it is expected …
Genome-wide association studies: progress and potential for drug discovery and development
Although genetic studies have been critically important for the identification of therapeutic
targets in Mendelian disorders, genetic approaches aiming to identify targets for common …
targets in Mendelian disorders, genetic approaches aiming to identify targets for common …
[HTML][HTML] The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases
AJ Alsheikh, S Wollenhaupt, EA King, J Reeb… - BMC medical …, 2022 - Springer
Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …
created a critical need to experimentally validate the disease-associated variants, 90% of …
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci
Genome-wide association studies (GWASs) have identified many variants associated with
complex traits, but identifying the causal gene (s) is a major challenge. In the present study …
complex traits, but identifying the causal gene (s) is a major challenge. In the present study …
Laying a solid foundation for Manhattan–'setting the functional basis for the post-GWAS era'
Genome-wide association studies (GWAS) have identified more than 8900 genetic variants,
mainly single-nucleotide polymorphisms (SNPs), associated with hundreds of human traits …
mainly single-nucleotide polymorphisms (SNPs), associated with hundreds of human traits …
[HTML][HTML] From GWAS to gene: transcriptome-wide association studies and other methods to functionally understand GWAS discoveries
B Li, MD Ritchie - Frontiers in Genetics, 2021 - frontiersin.org
Since their inception, genome-wide association studies (GWAS) have identified more than a
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …
[PDF][PDF] The post-GWAS era: from association to function
MD Gallagher, AS Chen-Plotkin - The American Journal of Human …, 2018 - cell.com
During the past 12 years, genome-wide association studies (GWASs) have uncovered
thousands of genetic variants that influence risk for complex human traits and diseases. Yet …
thousands of genetic variants that influence risk for complex human traits and diseases. Yet …
[HTML][HTML] Functional studies of GWAS variants are gaining momentum
F Lichou, G Trynka - Nature communications, 2020 - nature.com
Rapidly advancing genomic technologies and cross-disciplinary partnerships are
accelerating the biological and clinical interpretation of genome-wide association studies …
accelerating the biological and clinical interpretation of genome-wide association studies …