Over the past years, concerns have heightened over the escalating numbers of pathogenic
microorganisms isolated that are resistant to multiple antibiotics (Berkelman et al. 1994 …

ATP‐binding cassette (ABC) transporters share significant sequence identity within their
ATP‐binding domains. Degenerate oligonucleotides based on highly conserved portions of …

Multidrug resistance (MDR) efflux pumps in pathogenic microorganisms nullify the effects of
antimicrobial drugs used in medicine. We have conducted phylogenetic analyses showing …

We report results on the functional analysis of Saccharomyces cerevisiae ORF YNL065w,
predicted to code for a protein belonging to the poorly characterized major facilitator …

In this work, we report results on the functional analysis of Saccharomyces cerevisiae ORF
YGR224w, predicted to code for an integral membrane protein, with 14 potential …

Multidrug transporters have long puzzled researchers because of their ability to extrude
multiple structurally dissimilar toxic chemotherapeutic agents. They appear to be essentially …

The biological membrane covers all living cells and provides an effective barrier against the
passage of biologically important water-soluble solutes. This natural passage barrier is …

A major problem in chemotherapeutic treatment of many pathological conditions including
cancer and fungal infections is the development of a multidrug-resistant state in the target …

Previous work defined several families of secondary active transporters, including the
prokaryotic small multidrug resistance (SMR) and rhamnose transporter (RhaT) families as …

As integral membrane proteins demonstrating an extraordinarily wide substrate range, some
degree of regulatory control over the expression of bacterial multidrug-resistance (MDR) …