Background: Epigenetic features such as DNA hypomethylation have been associated with
conditions related to cardiovascular risk. We evaluated whether lower blood DNA …

BACKGROUND: Lower blood DNA methylation has been associated with atherosclerosis
and high cardiovascular risk. Mechanisms linking DNA hypomethylation to increased …

Epidemiological studies have demonstrated that genetic, environmental, behavioral, and
clinical factors contribute to cardiovascular disease development. How these risk factors …

Background: DNA methylation is implicated in coronary heart disease (CHD), but current
evidence is based on small, cross-sectional studies. We examined blood DNA methylation …

Importance American Indian communities experience a high burden of coronary heart
disease (CHD). Strategies are needed to identify individuals at risk and implement …

Objective. The lifespan of dialysis patients is as short as in patients with metastatic cancer
disease, mainly due to cardiovascular disease (CVD). DNA methylation is an important …

Background Estimates of global DNA methylation from repetitive DNA elements, such as Alu
and LINE-1, have been increasingly used in epidemiological investigations because of their …

Background Elevated serum homocysteine is associated with an increased risk of
cardiovascular disease (CVD). This may reflect a reduced systemic remethylation capacity …

Background DNA methylation profiles are responsive to environmental stimuli and metabolic
shifts. This makes DNA methylation a potential biomarker of environmental-related and …

Background DNA methylation changes over life at specific sites in the genome, which can
be used to estimate “biological age.” The aim of this population‐based longitudinal cohort …