A dual pharmacological strategy against COVID-19: The therapeutic potential of metformin and atorvastatin

LA De Jesús-González, RM Del Ángel… - Microorganisms, 2024 - mdpi.com
Metformin (MET) and atorvastatin (ATO) are promising treatments for COVID-19. This review
explores the potential of MET and ATO, commonly prescribed for diabetes and dyslipidemia …

Unveiling the potential pleiotropic effects of metformin in treating COVID-19: A comprehensive review

P Petakh, I Kamyshna, A Kamyshnyi - Frontiers in Molecular …, 2023 - frontiersin.org
This review article explores the potential of metformin, a medication commonly used for type
2 diabetes, as an antiviral and anti-inflammatory agent in the context of coronavirus disease …

Therapeutic potential of metformin in COVID-19: reasoning for its protective role

SM Samuel, E Varghese, D Büsselberg - Trends in microbiology, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections present with
increased disease severity and poor clinical outcomes in diabetic patients compared with …

[HTML][HTML] A review on protective roles and potential mechanisms of metformin in diabetic patients diagnosed with COVID-19

ZD Kifle, AE Woldeyohanis, CA Demeke - Metabolism Open, 2021 - Elsevier
The novel coronavirus disease 2019 (COVID‐19), is currently the leading threat to public
health and a huge challenge to the healthcare systems across the globe and caused by …

[HTML][HTML] Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potential

O Kamyshnyi, V Matskevych, T Lenchuk… - Biomedicine & …, 2021 - Elsevier
The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has become a serious
challenge for medicine and science. Analysis of the molecular mechanisms associated with …

Immunomodulatory and antiviral activity of metformin and its potential implications in treating coronavirus disease 2019 and lung injury

X Chen, H Guo, L Qiu, C Zhang, Q Deng… - Frontiers in …, 2020 - frontiersin.org
The pandemic of coronavirus disease 2019 (COVID-19), a disease which causes severe
lung injury and multiple organ damage, presents an urgent need for new drugs. The case …

Metformin in SARS-CoV-2 infection: A hidden path–from altered inflammation to reduced mortality. A review from the literature

AR Pedrosa, DC Martins, M Rizzo… - Journal of Diabetes and its …, 2023 - Elsevier
SARS-CoV-2 infection has been a major threat to human health and a huge challenge to
Medicine. In only two years, COVID-19 affected> 350 million people, causing> 5.6 million …

Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of Metformin intervention and the scientific basis of drug repurposing

E Varghese, SM Samuel, A Liskova, P Kubatka… - PLoS …, 2021 - journals.plos.org
Coronavirus Disease 2019 (COVID-19), caused by a new strain of coronavirus called
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was declared a …

Metformin as a potential treatment for COVID-19

MW MCCarthy - Expert Opinion on Pharmacotherapy, 2023 - Taylor & Francis
Introduction Early treatment for SARS-CoV-2 infection is essential to limit the clinical
progression of COVID-19. However, limited therapeutic options are available for standard …

Repurposing Revisited: Exploring the Role of Metformin for Treatment of Coronavirus Disease 2019

MJ Siedner, PE Sax - Clinical Infectious Diseases, 2024 - academic.oup.com
Approximately 4 years into the coronavirus disease 2019 (COVID-19) pandemic, available
treatment options for outpatients have a mixed track record. The most notable success is …