Nucleolar stress: From development to cancer

MC Lafita-Navarro, M Conacci-Sorrell - Seminars in cell & developmental …, 2023 - Elsevier
The nucleolus is a large nuclear membraneless organelle responsible for ribosome
biogenesis. Ribosomes are cytoplasmic macromolecular complexes comprising RNA and …

[HTML][HTML] Nucleolar Stress: hallmarks, sensing mechanism and diseases

K Yang, J Yang, J Yi - Cell stress, 2018 - ncbi.nlm.nih.gov
The nucleolus is a prominent subnuclear compartment, where ribosome biosynthesis takes
place. Recently, the nucleolus has gained attention for its novel role in the regulation of …

Nucleolus and nucleolar stress: from cell fate decision to disease development

L Hua, D Yan, C Wan, B Hu - Cells, 2022 - mdpi.com
Besides the canonical function in ribosome biogenesis, there have been significant recent
advances towards the fascinating roles of the nucleolus in stress response, cell destiny …

Nucleolar function in lifespan regulation

V Tiku, A Antebi - Trends in cell biology, 2018 - cell.com
The nucleolus is a prominent membraneless organelle residing within the nucleus. The
nucleolus has been regarded as a housekeeping structure mainly known for its role in …

Nucleolar and ribosomal DNA structure under stress: yeast lessons for aging and cancer

E Matos-Perdomo, F Machín - Cells, 2019 - mdpi.com
Once thought a mere ribosome factory, the nucleolus has been viewed in recent years as an
extremely sensitive gauge of diverse cellular stresses. Emerging concepts in nucleolar …

The multifunctional nucleolus

FM Boisvert, S Van Koningsbruggen… - … reviews Molecular cell …, 2007 - nature.com
The nucleolus is a distinct subnuclear compartment that was first observed more than 200
years ago. Nucleoli assemble around the tandemly repeated ribosomal DNA gene clusters …

Ribosomal proteins control or bypass p53 during nucleolar stress

A Russo, G Russo - International journal of molecular sciences, 2017 - mdpi.com
The nucleolus is the site of ribosome biogenesis, a complex process that requires the
coordinate activity of all three RNA polymerases and hundreds of non-ribosomal factors that …

Therapeutic approaches targeting nucleolus in cancer

P Carotenuto, A Pecoraro, G Palma, G Russo, A Russo - Cells, 2019 - mdpi.com
The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed
more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and …

The relationship between the nucleolus and cancer: Current evidence and emerging paradigms

I Orsolic, D Jurada, N Pullen, M Oren… - Seminars in cancer …, 2016 - Elsevier
The nucleolus is the most prominent nuclear substructure assigned to produce ribosomes;
molecular machines that are responsible for carrying out protein synthesis. To meet the …

[HTML][HTML] New insights into nucleolar structure and function

YW Lam, L Trinkle-Mulcahy - F1000prime reports, 2015 - ncbi.nlm.nih.gov
The nucleolus is a non-membrane-bound nuclear organelle found in all eukaryotes. It is the
quintessential 'RNA-seeded'nuclear body, forming around specific chromosomal features …