Background Activated microglia‐mediated inflammation plays a key role in the pathogenesis
of Alzheimer's disease (AD). In addition, chronic activation of NLRP 3 inflammasomes …

Emerging evidence indicates that the enhancement of microglial autophagy inhibits the
NLRP3 inflammasome mediated neuroinflammation in Alzheimer's disease (AD) …

Nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3)
inflammasome-mediated chronic neuroinflammation plays a crucial role in the progression …

Microglia-mediated neuroinflammation plays an important role in Alzheimer's disease
development. Resveratrol, a natural polyphenol from the Japanese knotweed (Polygonum …

Background/Aims: Microglial activation is an important pathological feature in the brains of
patients with Alzheimer's disease (AD), and amyloid-β (Aβ) peptides play a crucial role in …

Alzheimer's disease (AD) is the seventh most common cause of mortality and one of the
major causes of disability and vulnerability in the elderly. AD is characterized by gradual …

Background Numerous studies have found that inhibiting the expression of NLRP3
inflammasome can significantly improve depressive-like behaviors in mice, but the research …

Accumulating evidence has indicated that activation of microglia and neuroinflammation
reaction play a prominent role in Alzheimer's disease (AD). Inhibition of toll-like receptor 4 …

Purpose Neurodegenerative diseases are associated with neuroinflammation along with
activation of microglia and oxidative stress, but currently lack effective treatments …

Background Alzheimer's disease (AD) is a major clinical problem, but there is a distinct lack
of effective therapeutic drugs for this disease. We investigated the potential therapeutic …