Photoprotective role of epidermal melanin granules against ultraviolet damage and DNA repair in guinea pig skin

T Ishikawa, K Kodama, J Matsumoto, S Takayama - Cancer research, 1984 - AACR
We previously developed a quantitative autoradiographic technique with special forceps for
measuring unscheduled DNA synthesis (UDS) in mouse skin after treatment with ultraviolet …

Melanin reduces ultraviolet-induced DNA damage formation and killing rate in cultured human melanoma cells

N Kobayashi, T Muramatsu, Y Yamashina… - Journal of investigative …, 1993 - Elsevier
Epidermal melanin pigment is believed to prevent development of ultraviolet (UV)–induced
skin cancer by shielding cell nuclei and reducing DNA damage formation. It has not been …

Dose Response, Wavelength Dependence, and Time Course of Ultraviolet Radiation-induced Unscheduled DNA Synthesis in Mouse Skin in Vivo

K Kodama, T Ishikawa, S Takayama - Cancer research, 1984 - AACR
A new method for autoradiographic measurement of unscheduled DNA synthesis (UDS) in
the skin in vivo after treatment with ultraviolet light (UV) was developed. The skin of the back …

[HTML][HTML] The role of melanin in the induction of oxidative DNA base damage by ultraviolet A irradiation of DNA or melanoma cells

E Kvam, RM Tyrrell - Journal of Investigative Dermatology, 1999 - Elsevier
Highly pigmented, dark skin is more resistant to the harmful effects of solar ultraviolet
radiation than light-colored human skin. The extent to which tanning protects skin from …

Attenuation of DNA Damage in the Dermis and Epidermis of the Albino Hairless Mouse by Chronic Exposure to Ultraviolet‐A and‐B Radiation¶

DL Mitchell, M Byrom, S Chiarello… - Photochemistry and …, 2001 - Wiley Online Library
Mammalian skin is vulnerable to the photocarcinogenic and photoaging effects of solar UV
radiation and defends itself using a variety of photoprotective responses including epidermal …

[HTML][HTML] Supranuclear melanin caps reduce ultraviolet induced DNA photoproducts in human epidermis

N Kobayashi, A Nakagawa, T Muramatsu… - Journal of Investigative …, 1998 - Elsevier
Melanin can form supranuclear caps in human epidermis, suggesting that intracellular
melanin reduces ultraviolet transmission to underlying cell nuclei and inhibits the formation …

Comparison of the responses of human melanocytes with different melanin contents to ultraviolet B irradiation

D Barker, K Dixon, EE Medrano, D Smalara, S Im… - Cancer Research, 1995 - AACR
Melanin is thought to serve in photoprotection. To investigate this, we have compared the
responses of cultured human melanocytes derived from different pigmentary phenotypes …

Quantitative detection of ultraviolet light‐induced photoproducts in mouse skin by immunohistochemistry

X Qin, S Zhang, H Oda, Y Nakatsuru… - Japanese journal of …, 1995 - Wiley Online Library
UVB‐induced cyclobutane pyrimidine dimers (CPDs) and pyrimidine‐pyrimidone (6‐4)
photoproducts [(6‐4) photoproducts] in mouse skin DNA were quantitatively measured using …

Quantitation and visualization of ultraviolet‐induced DNA damage using specific antibodies: application to pigment cell biology

N Kobayashi, S Katsumi, K Imoto… - Pigment cell …, 2001 - Wiley Online Library
The major types of DNA damage induced by sunlight in the skin are DNA photoproducts,
such as cyclobutane pyrimidine dimers (CPDs),(6‐4) photoproducts (6‐4PPs) and Dewar …

UV-induced unscheduled DNA synthesis in guinea pig skin melanocytes isolated in culture

G Moreno, F Vinzens, M Prunieras - Journal of Investigative Dermatology, 1978 - Elsevier
Pigmented melanocytes isolated in culture from the epidermis of guinea pig ears were used
to study the unscheduled DNA synthesis (UDS) induced by ultraviolet (UV) irradiation at 254 …