Waist circumference (WC) and waist-to-hip ratio (WHR) are surrogate measures of central
adiposity that are associated with adverse cardiovascular events, type 2 diabetes and …

Genome-wide discovery efforts have identified more than 500 genetic loci associated with
adiposity traits. The vast majority of these loci were found through large-scale meta-analyses …

Results: Of the 17 WHR loci, eight single-nucleotide polymorphisms (SNPs) located in four
loci were replicated in the sex-combined or sex-stratified meta-analyses. Two of these eight …

More than one in three adults worldwide is either overweight or obese. Epidemiological
studies indicate that the location and distribution of excess fat, rather than general adiposity …

Aim This study aims to investigate the associations between genetic risk scores (GRS) for
favourable and unfavourable adiposity and a wide range of adiposity‐related outcomes …

Genome-wide association studies (GWAS) in predominately European-ancestry (EUR)
populations have identified numerous genetic variants associated with adiposity-related …

Abstract The Genetic Investigation of Anthropometric Traits (GIANT) consortium identified 14
loci in European Ancestry (EA) individuals associated with waist-to-hip ratio (WHR) adjusted …

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-
analysis of 16 genome-wide association studies (GWAS, N= 38,580) informative for adult …

Polymorphisms in adipokine genes, such as leptin (LEP), leptin receptor (LEPR), resistin
(RETN), adiponectin (ADIPOQ), interleukin‐1β (IL‐1β), IL‐6 (IL‐6), and tumor necrosis factor …

To increase our understanding of the genetic basis of adiposity and its links to
cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of …