Importance of the field: Antibiotics have existed in the environment for millennia, but it has
only been in the past 80 years that humans have used them systematically to treat infections …

Importance of the field: Antibacterial drug discovery and development has slowed
considerably in recent years, with novel classes discovered decades ago and regulatory …

Today, antibacterial drug resistance has turned into a significant public health issue.
Repeated intake, suboptimal and/or unnecessary use of antibiotics, and, additionally, the …

Increasing antibiotic resistance in microorganisms and new emerging pathogens have
become a major problem in our society. Rising to satisfy this urgent medical need is a recent …

The discovery of drugs used to combat infectious diseases is in the process of constant
change to address the ever-worsening problem of antibiotic resistance in pathogens and a …

Although there has been a relentless increase in resistance to antimicrobial agents amongst
important bacterial pathogens throughout the world, it is well known that the number of new …

Antibacterial research has evolved dramatically over the past five decades. Early work relied
on serendipity of finding drug-like molecules, usually natural products that had desirable …

Bacterial resistance is inevitable and is a growing concern. It can be addressed only by
discovery and development of new agents. However the discovery and development of new …

Antibiotic (antibacterial) resistance is a serious global problem and the need for new
treatments is urgent. The current antibiotic discovery model is not delivering new agents at a …

The rational design of pharmaceutical agents with activity against bacterial targets presents
several unique challenges due to the significant differences in the target bacterial cells and …