Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2011–2014)

X Li, L Zhang, Y Tian, Y Song, P Zhan… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: There is a continuous need for next-generation non-nucleoside RT inhibitors
(NNRTIs) with different resistance profiles, improved safety, excellent tolerability, and …

Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2005–2010)

P Zhan, X Liu - Expert opinion on therapeutic patents, 2011 - Taylor & Francis
Introduction: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) form the backbone of
antiretroviral treatment for many HIV-infected individuals. The unique antiviral activity, high …

Non-nucleoside reverse transcriptase inhibitors: the NNRTI boom

OS Pedersen, EB Pedersen - Antiviral Chemistry and …, 1999 - journals.sagepub.com
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are promising drugs for the
treatment of HIV when used in combination with other anti-HIV drugs such as nucleoside …

Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives

G Campiani, A Ramunno, G Maga… - Current …, 2002 - ingentaconnect.com
Along with nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs),
nonnucleoside reverse transcriptase inhibitors (NNRTIs) have gained a definitive and …

The journey of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) from lab to clinic

V Namasivayam, M Vanangamudi… - Journal of medicinal …, 2018 - ACS Publications
Human immunodeficiency virus (HIV) infection is now pandemic. Targeting HIV-1 reverse
transcriptase (HIV-1 RT) has been considered as one of the most successful targets for the …

Development of non-nucleoside reverse transcriptase inhibitors for anti-HIV therapy

C Sahlberg, XX Zhou - Anti-Infective Agents in Medicinal …, 2008 - ingentaconnect.com
The NNRTIs play an important role in the present therapy against HIV/AIDS. This review
discusses the basic principles in the development of NNRTIs for HIV therapy. It also …

Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: a review of the last 20 years (1989 …

MP de Béthune - Antiviral research, 2010 - Elsevier
It is almost 20 years since NNRTIs were identified as a new class of antiretroviral drugs for
the treatment of HIV-1 infection. Although they belong to different and diverse chemical …

Recent advances in the discovery and development of novel HIV-1 NNRTI platforms: 2006-2008 update

P Zhan, X Liu, Z Li - Current medicinal chemistry, 2009 - ingentaconnect.com
Currently, the long-term usage of non-nucleoside reverse transcriptase inhibitors (NNRTIs)
in HIV/AIDS patients eventually leads to the development of drug resistance and severe side …

Strategies for the design of HIV-1 non-nucleoside reverse transcriptase inhibitors: lessons from the development of seven representative paradigms

D Li, P Zhan, E De Clercq, X Liu - Journal of medicinal chemistry, 2012 - ACS Publications
Currently, five NNRTIs have been approved by US Food and Drug Administration (US FDA)
for the clinical treatment of AIDS, ie, nevirapine, delavirdine, efavirenz, etravirine, and …

Developing novel nonnucleoside HIV-1 reverse transcriptase inhibitors: beyond the butterfly

A Basavapathruni, KS Anderson - Current pharmaceutical …, 2006 - ingentaconnect.com
To date three nonnucleoside reverse transcriptase inhibitors (NNRTIs) have been approved
by the US Food and Drug Administration for the treatment of human immunodeficiency virus …