[HTML][HTML] Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening

JS Schardt, G Pornnoppadol, AA Desai, KS Park… - Scientific Reports, 2021 - nature.com
Monoclonal antibodies that target SARS-CoV-2 with high affinity are valuable for a wide
range of biomedical applications involving novel coronavirus disease (COVID-19) …

A novel high-throughput single B-cell cloning platform for isolation and characterization of high-affinity and potent SARS-CoV-2 neutralizing antibodies

P Prashar, S Swain, N Adhikari, P Aryan, A Singh… - Antiviral Research, 2022 - Elsevier
Monoclonal antibodies (mAbs) that are specific to SARS-CoV-2 can be useful in diagnosing,
preventing, and treating the coronavirus (COVID-19) illness. Strategies for the high …

[PDF][PDF] Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients' B cells

Y Cao, B Su, X Guo, W Sun, Y Deng, L Bao, Q Zhu… - Cell, 2020 - cell.com
The COVID-19 pandemic urgently needs therapeutic and prophylactic interventions. Here,
we report the rapid identification of SARS-CoV-2-neutralizing antibodies by high-throughput …

[HTML][HTML] Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster

SSF Lende, NM Barnkob, RW Hansen, H Bansia… - Plos one, 2023 - journals.plos.org
Despite development of effective SARS-CoV-2 vaccines, a sub-group of vaccine non-
responders depends on therapeutic antibodies or small-molecule drugs in cases of severe …

Neutralizing antibodies isolated by a site-directed screening have potent protection on SARS-CoV-2 infection

X Liu, F Gao, L Gou, Y Chen, Y Gu, L Ao, H Shen, Z Hu… - 2020 - europepmc.org
Neutralizing antibody is one of the most effective interventions for acute pathogenic
infection. Currently, over three million people have been identified for SARS-CoV-2 infection …

[HTML][HTML] Fast-Track Discovery of SARS-CoV-2-Neutralizing Antibodies from Human B Cells by Direct Functional Screening

M Hillenbrand, C Esslinger, J Seidenberg, M Weber… - Viruses, 2024 - mdpi.com
As the COVID-19 pandemic revealed, rapid development of vaccines and therapeutic
antibodies are crucial to guarantee a quick return to the status quo of society. In early 2020 …

[PDF][PDF] Potent neutralizing broad-spectrum antibody against SARS-CoV-2 generated from dual-antigen-specific B cells from convalescents

M Takeshita, H Fukuyama, K Kamada, T Matsumoto… - Iscience, 2023 - cell.com
Several antibody therapeutics have been developed against SARS-CoV-2; however, they
have attenuated neutralizing ability against variants. In this study, we generated multiple …

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

BE Jones, PL Brown-Augsburger, KS Corbett… - BioRxiv, 2020 - biorxiv.org
SARS-CoV-2 poses a public health threat for which therapeutic agents are urgently needed.
Herein, we report that high-throughput microfluidic screening of antigen-specific B-cells led …

IMM-BCP-01, a patient-derived anti–SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA. 1 and BA. 2

PA Nikitin, JM DiMuzio, JP Dowling, NB Patel… - Science …, 2022 - science.org
Monoclonal antibodies are an efficacious therapy against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). However, rapid viral mutagenesis led to escape …

[HTML][HTML] Synthetic repertoires derived from convalescent COVID-19 patients enable discovery of SARS-CoV-2 neutralizing antibodies and a novel quaternary binding …

J Goike, CL Hsieh, A Horton, EC Gardner, F Bartzoka… - Biorxiv, 2021 - ncbi.nlm.nih.gov
The ongoing evolution of SARS-CoV-2 into more easily transmissible and infectious variants
has sparked concern over the continued effectiveness of existing therapeutic antibodies and …