Mapping mutational effects along the evolutionary landscape of HIV envelope
HK Haddox, AS Dingens, SK Hilton, J Overbaugh… - Elife, 2018 - elifesciences.org
The immediate evolutionary space accessible to HIV is largely determined by how single
amino acid mutations affect fitness. These mutational effects can shift as the virus evolves …
amino acid mutations affect fitness. These mutational effects can shift as the virus evolves …
Experimental estimation of the effects of all amino-acid mutations to HIV's envelope protein on viral replication in cell culture
HK Haddox, AS Dingens, JD Bloom - PLoS pathogens, 2016 - journals.plos.org
HIV is notorious for its capacity to evade immunity and anti-viral drugs through rapid
sequence evolution. Knowledge of the functional effects of mutations to HIV is critical for …
sequence evolution. Knowledge of the functional effects of mutations to HIV is critical for …
Frequent toggling between alternative amino acids is driven by selection in HIV-1
Host immune responses against infectious pathogens exert strong selective pressures
favouring the emergence of escape mutations that prevent immune recognition. Escape …
favouring the emergence of escape mutations that prevent immune recognition. Escape …
Adaptation in the env Gene of HIV-1 and Evolutionary Theories of Disease Progression
S Williamson - Molecular biology and evolution, 2003 - academic.oup.com
The exact mechanisms by which HIV overwhelms the immune system remain poorly
understood. Among the several explanations of HIV disease progression, most include …
understood. Among the several explanations of HIV disease progression, most include …
Coordinate linkage of HIV evolution reveals regions of immunological vulnerability
Cellular immune control of HIV is mediated, in part, by induction of single amino acid
mutations that reduce viral fitness, but compensatory mutations limit this effect. Here, we …
mutations that reduce viral fitness, but compensatory mutations limit this effect. Here, we …
Quantifying Selection against Synonymous Mutations in HIV-1 env Evolution
Intrapatient evolution of human immunodeficiency virus type 1 (HIV-1) is driven by the
adaptive immune system resulting in rapid change of HIV-1 proteins. When cytotoxic CD8+ T …
adaptive immune system resulting in rapid change of HIV-1 proteins. When cytotoxic CD8+ T …
Within-host and between-host evolutionary rates across the HIV-1 genome
Background HIV evolves rapidly at the epidemiological level but also at the within-host level.
The virus' within-host evolutionary rates have been argued to be much higher than its …
The virus' within-host evolutionary rates have been argued to be much higher than its …
Molecular mechanisms of recombination restriction in the envelope gene of the human immunodeficiency virus
E Simon-Loriere, R Galetto, M Hamoudi… - PLoS …, 2009 - journals.plos.org
The ability of pathogens to escape the host's immune response is crucial for the
establishment of persistent infections and can influence virulence. Recombination has been …
establishment of persistent infections and can influence virulence. Recombination has been …
Evolution of the human immunodeficiency virus envelope gene is dominated by purifying selection
The evolution of the human immunodeficiency virus (HIV-1) during chronic infection involves
the rapid, continuous turnover of genetic diversity. However, the role of natural selection …
the rapid, continuous turnover of genetic diversity. However, the role of natural selection …
An evolutionary-network model reveals stratified interactions in the V3 loop of the HIV-1 envelope
The third variable loop (V3) of the human immunodeficiency virus type 1 (HIV-1) envelope is
a principal determinant of antibody neutralization and progression to AIDS. Although it is …
a principal determinant of antibody neutralization and progression to AIDS. Although it is …