The m6A methyltransferase METTL3 is functionally implicated in DLBCL development by regulating m6A modification in PEDF

Y Cheng, Y Fu, Y Wang, J Wang - Frontiers in Genetics, 2020 - frontiersin.org
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of lymphoma, whose
treatment still has a major challenge of achieving a satisfactory curative effect. The …

Novel insights into mutual regulation between N6-methyladenosine modification and LncRNAs in tumors

N Zhang, Y Sun, Z Mei, Z He, S Gu - Cancer Cell International, 2023 - Springer
Abstract N6-methyladenosine (m6A), one of the most common RNA methylation
modifications, has emerged in recent years as a new layer of the regulatory mechanism …

METTL3‑mediated m6A modification of Bcl‑2 mRNA promotes non‑small cell lung cancer progression Corrigendum in/10.3892/or. 2023.8502

Y Zhang, S Liu, T Zhao, C Dang - Oncology Reports, 2021 - spandidos-publications.com
Abstract Methyltransferase‑like 3 (METTL3) is an RNA methyltransferase that mediates
modification of N6‑methyladenosine (m6A), which serves as an oncogene in various types …

The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the …

S Wanna-Udom, M Terashima, H Lyu… - Biochemical and …, 2020 - Elsevier
Abstract N6-Methyladenosine (m6A) is the most common internal chemical modification of
mRNAs involved in many pathological processes including various cancers. In this study, we …

The m6A methyltransferase METTL14 inhibits the proliferation, migration, and invasion of gastric cancer by regulating the PI3K/AKT/mTOR signaling pathway

X Liu, M Xiao, L Zhang, L Li, G Zhu… - Journal of clinical …, 2021 - Wiley Online Library
Abstract Background N6‐methyladenosine (m6A) modification may participate in the
regulation of occurrence and development of tumors. However, the m6A level and the …

METTL3 intensifies the progress of oral squamous cell carcinoma via modulating the m6A amount of PRMT5 and PD‐L1

Y Ai, S Liu, H Luo, S Wu, H Wei, Z Tang… - Journal of …, 2021 - Wiley Online Library
N6‐Methyladenosine (m6A) modification is one of the commonest chemical modifications in
eukaryotic mRNAs, which has essential effects on mRNA translation, splicing, and stability …

[HTML][HTML] METTL3 plays multiple functions in biological processes

S Liu, L Zhuo, J Wang, Q Zhang, Q Li, G Li… - American journal of …, 2020 - ncbi.nlm.nih.gov
Abstract N 6-methyladenosine (m 6 A) is the most common internal modification of mRNAs
in higher eukaryotic. This process is performed by methyltransferase. Methyltransferase-like …

m6A methylation regulates osteoblastic differentiation and bone remodeling

M Huang, S Xu, L Liu, M Zhang, J Guo… - Frontiers in cell and …, 2021 - frontiersin.org
Osteoporosis is a prevalent bone disease of the aging population, which is characterized by
a decrease in bone mass because of the imbalance of bone metabolism. Although the …

m6A methyltransferase METTL3 maintains colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation

J Xu, Q Chen, K Tian, R Liang, T Chen… - Oncology …, 2020 - spandidos-publications.com
Abstract N6‑methyladenosine (m6A) RNA modification maintained by N6‑
methyltransferases and demethylases is involved in multiple biological functions …

METTL3‐m6A methylase regulates the osteogenic potential of bone marrow mesenchymal stem cells in osteoporotic rats via the Wnt signalling pathway

T Wu, H Tang, J Yang, Z Yao, L Bai, Y Xie, Q Li… - Cell …, 2022 - Wiley Online Library
Objectives Bone marrow mesenchymal stem cells (BMSCs) hold a high osteogenic
differentiation potential, but the mechanisms that control the osteogenic ability of BMSCs …