Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine
storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been …

Background Currently, JAK-inhibitors are repurposed for therapy of Covid-19 because of
their ability in restraining immune response, yet the corroboration regarding their advantage …

Objectives This systematic review and meta-analysis of randomized controlled trials (RCTs)
aimed to investigate the clinical efficacy and safety of Janus kinase (JAK) inhibitors for …

Background In inflamed tissue, immune cells are accumulated, and various intercellular
signals are involved in the pathogenesis. Janus kinases (JAKs) are typical tyrosine kinases …

Background With potential antiviral and anti‐inflammatory properties, Janus kinase (JAK)
inhibitors represent a potential treatment for symptomatic severe acute respiratory syndrome …

We are witnessing a paradigm shift in drug development and clinical practice to fight the
novel coronavirus disease (COVID-19), and a number of clinical trials have been or are …

Background Cytokine storm observed in patients with severe Coronavirus Disease 2019
(COVID-19) contributes to poor clinical outcomes and increased mortality. Janus kinases …

Recent evidence proposed that the severity of the coronavirus disease 2019 (COVID-19) in
patients is a consequence of cytokine storm, characterized by increased IL-1β, IL-6, IL-18 …

Cytokine signaling, especially interferon (IFN) signaling is closely linked to several aspects
of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. During initial …

Abstract Coronavirus disease-2019 (COVID-19) represents a global public health
nightmare. The “cytokine storm,” the most prominent underlying pathophysiologic …