Therapeutic potential of endothelial progenitor cells in the field of orthopaedics

Y Kawakami, T Matsumoto, Y Mifune… - Current Stem Cell …, 2017 - ingentaconnect.com
Inadequate blood supply frequently impedes the viability of tissue-engineered constructs in
the initial phase after implantation, and can lead to improper cell integration or cell death …

An emerging cell-based strategy in orthopaedics: endothelial progenitor cells

K Atesok, T Matsumoto, J Karlsson, T Asahara… - Knee Surgery, Sports …, 2012 - Springer
Purpose The purpose of this article was to analyze the results of studies in the literature,
which evaluated the use of endothelial progenitor cells (EPCs) as a cell-based tissue …

Endothelial progenitor cells: a novel cell-based therapy in orthopaedic surgery

K Atesok, R Li, E Schemitsch - JAAOS-Journal of the American …, 2012 - journals.lww.com
Positive effects of EPC therapy have been demonstrated in ligament tissue regeneration, as
well. Matsumoto et al8 recently demonstrated that CD34-and CD146-expressing vascular …

Differential analysis of peripheral blood‐and bone marrow‐derived endothelial progenitor cells for enhanced vascularization in bone tissue engineering

AR Amini, CT Laurencin… - Journal of orthopaedic …, 2012 - Wiley Online Library
For tissue engineering applications, effective bone regeneration requires rapid neo‐
vascularization of implanted grafts to ensure the survival of cells in the early post …

Subtypes of endothelial progenitor cells affect healing of segmental bone defects differently

EM Giles, C Godbout, W Chi, MA Glick, T Lin… - International …, 2017 - Springer
Purpose Treating fracture nonunion with endothelial progenitor cells (EPCs) is a promising
approach. Nevertheless, the effect of different EPC-related cell populations remains unclear …

Circulating endothelial/skeletal progenitor cells for bone regeneration and healing

T Matsumoto, R Kuroda, Y Mifune, A Kawamoto… - Bone, 2008 - Elsevier
An emerging strategy in the regeneration and repair of bone is to use stem cells, including
bone marrow mesenchymal stem cells, which are the most investigated and reliable source …

Stem cell therapy in bone repair and regeneration

N Zaidi, AJ Nixon - Annals of the New York Academy of …, 2007 - Wiley Online Library
Stem cells of various origins, particularly endothelial progenitor cells (EPCs), have potential
to enhance bone repair and regeneration. EPCs are resident in the bone marrow and home …

The use of endothelial progenitor cells for the regeneration of musculoskeletal and neural tissues

N Kamei, K Atesok, M Ochi - Stem cells international, 2017 - Wiley Online Library
Endothelial progenitor cells (EPCs) derived from bone marrow and blood can differentiate
into endothelial cells and promote neovascularization. In addition, EPCs are a promising cell …

Endothelial Progenitor Cell Therapy for Fracture Healing: A Dose‐Response Study in a Rat Femoral Defect Model

DJ Ramnaraign, C Godbout, K Hali… - Journal of Tissue …, 2023 - Wiley Online Library
Endothelial progenitor cell (EPC) therapy has been successfully used in orthopaedic
preclinical models to heal bone defects. However, no previous studies have investigated the …

Endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs) in bone healing

NC Keramaris, S Kaptanis, H Lucy Moss… - Current stem cell …, 2012 - ingentaconnect.com
Fracture healing is a complex physiological process. Local vascularity at the site of the
fracture has been established as one of the most important factors influencing the healing …