Resistance-resistant antibacterial treatment strategies

JI Batchelder, PJ Hare, WWK Mok - Frontiers in antibiotics, 2023 - frontiersin.org
Antibiotic resistance is a major danger to public health that threatens to claim the lives of
millions of people per year within the next few decades. Years of necessary administration …

Antibiotic alternatives and combinational therapies for bacterial infections

S Sillankorva, MO Pereira, M Henriques - Frontiers in microbiology, 2019 - frontiersin.org
“The thoughtless person playing with penicillin treatment is morally responsible for the death
of the man who succumbs to infection with the penicillin-resistant organism.” As Alexander …

Repurposing Antibiotics to Treat Resistant Gram‐Negative Pathogens

F Schweizer - Antibiotic Drug Resistance, 2019 - Wiley Online Library
Summary Antibiotic Resistance in Gram‐negative bacteria remains one of the most pressing
global health challenges. Our inability to discover novel antibacterial agents against Gram …

[HTML][HTML] Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria

Y Liu, Z Tong, J Shi, R Li, M Upton, Z Wang - Theranostics, 2021 - ncbi.nlm.nih.gov
Antimicrobial resistance has been a global health challenge that threatens our ability to
control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new …

Combination approaches to combat multidrug-resistant bacteria

RJ Worthington, C Melander - Trends in biotechnology, 2013 - cell.com
The increasing prevalence of infections caused by multidrug-resistant bacteria is a global
health problem that has been exacerbated by the dearth of novel classes of antibiotics …

[图书][B] Antimicrobials: new and old molecules in the fight against multi-resistant bacteria

F Marinelli, O Genilloud - 2013 - books.google.com
Reports on the emergence and prevalence of resistant bacterial infections in hospitals and
communities raise concerns that we may soon no longer be able to rely on antibiotics as a …

Antibiotic adjuvants: diverse strategies for controlling drug‐resistant pathogens

EE Gill, OL Franco… - Chemical biology & drug …, 2015 - Wiley Online Library
The growing number of bacterial pathogens that are resistant to numerous antibiotics is a
cause for concern around the globe. There have been no new broad‐spectrum antibiotics …

Multi-arming ourselves against drug-resistant bacteria

J Raherisoanjato, MT Henke - Cell Host & Microbe, 2023 - cell.com
New classes of antibiotics are desperately needed in our fight against antibiotic-resistant
bacterial infections. Jia et al. publish a new" multi-armed" antibiotic scaffold that effectively …

New drugs, approaches, and strategies to combat antimicrobial resistance

CK Singh, KK Sodhi, MS Mubarak - Frontiers in Pharmacology, 2023 - frontiersin.org
Multidrug-resistant organisms (MDROs) are microorganisms, mainly bacteria, that have
become resistant to one or more classes of antimicrobial agents and to certain antibiotics …

The future challenges facing the development of new antimicrobial drugs

A Coates, Y Hu, R Bax, C Page - Nature reviews Drug discovery, 2002 - nature.com
The emergence of resistance to antibacterial agents is a pressing concern for human health.
New drugs to combat this problem are therefore in great demand, but as past experience …