The current burden associated to multidrug resistance, and the emerging superbugs, result
in a decreased and even loss of antibiotic efficacy, which poses significant challenges in the …

The introduction of effective antibacterial therapies for infectious diseases in the mid‐20th
century completely revolutionized clinical practices and helped to facilitate the development …

Antibiotic resistance occurs through several mechanisms that can coexist simultaneously in
the same cell. The main ones include modification of the target, reduced permeability, export …

The global threat of antibiotic resistance is steadily growing. Antibiotic resistance may
involve any class of antibiotic, including second-and third-line agents that have been …

The increasing emergence of multidrug-resistant bacteria is recognized as a major threat to
human health worldwide. While the use of small molecule antibiotics has enabled many …

Since their discovery in the early 20th century, antibiotics have been used as the primary
weapon against bacterial infections. Due to their prophylactic effect, they are also used as …

Infections are a growing global threat, and the number of resistant species of microbial
pathogens is alarming. However, the rapid development of cross-resistant or multidrug …

An increasing number of bacterial pathogens are acquiring resistance to the commonly used
antibiotics. This has spurred a global threat leading to a resistance era and has penetrated …

Antibiotic resistance is a problem that continues to challenge the healthcare sector. In
particular, multidrug resistance is now common in familiar pathogens such as …

New drugs for the antibacterial pipeline? | Nature Reviews Microbiology Skip to main
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