Transition Towards Antibiotic Hybrid Vehicles: The Next Generation Antibacterials

R Kuppusamy, K Browne, D Suresh… - Current Medicinal …, 2023 - ingentaconnect.com
Antibiotic resistance is a growing global health problem when the discovery and
development of novel antibiotics are diminishing. Various strategies have been proposed to …

Emerging non-traditional approaches to combat antibiotic resistance

AN Konwar, SN Hazarika, P Bharadwaj, D Thakur - Current Microbiology, 2022 - Springer
An increasing number of bacterial pathogens are acquiring resistance to the commonly used
antibiotics. This has spurred a global threat leading to a resistance era and has penetrated …

Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance

V Pokrovskaya, T Baasov - Expert opinion on drug discovery, 2010 - Taylor & Francis
Importance of the field: The emerging and sustained resistance to currently available
antibiotics and the poor pipeline of new antibacterials urgently call for the development of …

Call for next-generation drugs that remove the uptake barrier to combat antibiotic resistance

B Peng, H Li, X Peng - Drug Discovery Today, 2023 - Elsevier
Existing antibacterial agents can be categorized into two generations, but bacterial
insensitivity towards both of these classes poses a serious public health challenge …

Instructive advances in chemical microbiology inspired by nature's diverse inventory of molecules

K Liu, RW Huigens III - ACS infectious diseases, 2019 - ACS Publications
Natural product antibiotics have played an essential role in the treatment of bacterial
infection in addition to serving as useful tools to explore the intricate biology of bacteria. Our …

Solving the antibiotic crisis

GD Wright - ACS Infectious Diseases, 2015 - ACS Publications
Antibiotics are essential for both treating and preventing infectious diseases. Paradoxically,
despite their importance as pillars of modern medicine, we are in danger of losing antibiotics …

Multitarget antibacterial drugs: An effective strategy to combat bacterial resistance

J Feng, Y Zheng, W Ma, A Ihsan, H Hao… - Pharmacology & …, 2023 - Elsevier
The rise of antibiotic resistance and the decrease in the discovery of new antibiotics have
caused a global health crisis. Of particular concern is the fact that despite efforts to develop …

[HTML][HTML] Confronting the challenges of discovery of novel antibacterial agents

SB Singh - Bioorganic & medicinal chemistry letters, 2014 - Elsevier
Bacterial resistance is inevitable and is a growing concern. It can be addressed only by
discovery and development of new agents. However the discovery and development of new …

[PDF][PDF] Alternatives to antibiotics: future trends

A Dowling, J O'dwyer, CC Adley - Microbial pathogens and …, 2013 - academia.edu
The need for new antibiotics is greater than ever due to the emergence of multidrug resistant
pathogens. The value and importance of antibiotics cannot be overestimated, and they must …

Targeting non-multiplying organisms as a way to develop novel antimicrobials

ARM Coates, Y Hu - Trends in pharmacological sciences, 2008 - cell.com
Increasing resistance and decreasing numbers of antibiotics reaching the market point to a
growing need for novel antibacterial drugs. Most antibiotics are very inefficient at killing non …