An increasing number of bacterial pathogens are acquiring resistance to the commonly used antibiotics. This has spurred a global threat leading to a resistance era and has penetrated …
V Pokrovskaya, T Baasov - Expert opinion on drug discovery, 2010 - Taylor & Francis
Importance of the field: The emerging and sustained resistance to currently available antibiotics and the poor pipeline of new antibacterials urgently call for the development of …
B Peng, H Li, X Peng - Drug Discovery Today, 2023 - Elsevier
Existing antibacterial agents can be categorized into two generations, but bacterial insensitivity towards both of these classes poses a serious public health challenge …
Natural product antibiotics have played an essential role in the treatment of bacterial infection in addition to serving as useful tools to explore the intricate biology of bacteria. Our …
Antibiotics are essential for both treating and preventing infectious diseases. Paradoxically, despite their importance as pillars of modern medicine, we are in danger of losing antibiotics …
J Feng, Y Zheng, W Ma, A Ihsan, H Hao… - Pharmacology & …, 2023 - Elsevier
The rise of antibiotic resistance and the decrease in the discovery of new antibiotics have caused a global health crisis. Of particular concern is the fact that despite efforts to develop …
Bacterial resistance is inevitable and is a growing concern. It can be addressed only by discovery and development of new agents. However the discovery and development of new …
A Dowling, J O'dwyer, CC Adley - Microbial pathogens and …, 2013 - academia.edu
The need for new antibiotics is greater than ever due to the emergence of multidrug resistant pathogens. The value and importance of antibiotics cannot be overestimated, and they must …
ARM Coates, Y Hu - Trends in pharmacological sciences, 2008 - cell.com
Increasing resistance and decreasing numbers of antibiotics reaching the market point to a growing need for novel antibacterial drugs. Most antibiotics are very inefficient at killing non …